Three-dimensional quantification of circulation using finite-element methods in four-dimensional flow MR data of the thoracic aorta

dc.contributor.authorSotelo, Julio
dc.contributor.authorBissell, Malenka M.
dc.contributor.authorJiang, Yaxin
dc.contributor.authorMella, Hernan
dc.contributor.authorMura, Joaquín
dc.contributor.authorUribe, Sergio
dc.date.accessioned2022-11-30T02:47:00Z
dc.date.available2022-11-30T02:47:00Z
dc.date.issued2022
dc.description.abstractPurpose. Three-dimensional (3D) quantification of circulation using a Finite Elements methodology. Methods. We validate our 3D method using an in-silico arch model, for different mesh resolutions, image resolution and noise levels, and we compared this with a currently used 2D method. Finally, we evaluated the application of our methodology in 4D Flow MRI data of ascending aorta of six healthy volunteers, and six bicuspid aortic valve (BAV) patients, three with right and three with left handed flow, at peak systole. The in-vivo data was compared using a Mann-Whitney U-test between volunteers and patients (right and left handed flow). Results.The robustness of our method throughout different image resolutions and noise levels showed subestimation of circulation less than 45 cm2/s in comparison with the 55cm2/s generated by the current 2D method. The circulation (mean ± SD) of the healthy volunteer group was 13.83 ± 28.78 cm2/s, in BAV patients with right-handed flow 724.37 ± 317.53 cm2/s, and BAV patients with left-handed flow −480.99 ± 387.29 cm2/s. There were significant differences between healthy volunteers and BAV patients groups (P-value < .01), and also between BAV patients with a right-handed or left-handed helical flow and healthy volunteers (P-value < .01). Conclusion. We propose a novel 3D formulation to estimate the circulation in the thoracic aorta, which can be used to assess the differences between normal and diseased hemodynamic from 4D-Flow MRI data. This method also can correctly differentiate between the visually seen right- and left-handed helical flow, which suggests that this approach may have high clinical sensitivity, but requires confirmation in longitudinal studies with a large cohort.en_ES
dc.facultadFacultad de Ingenieríaen_ES
dc.file.nameSotelo_Thr2022.pdf
dc.identifier.doihttps://doi.org/10.1002/mrm.29004
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7548
dc.languageen
dc.publisherWiley
dc.sourceMagnetic Resonance in Medicine
dc.subject4D FLOW MRIen_ES
dc.subjectBICUSPID AORTIC VALVEen_ES
dc.subjectCIRCULATIONen_ES
dc.subjectFINITE ELEMENTSen_ES
dc.subjectHEMODYNAMIC PARAMETERSen_ES
dc.titleThree-dimensional quantification of circulation using finite-element methods in four-dimensional flow MR data of the thoracic aorta
dc.typeArticulo
uv.departamentoEscuela de Ingenieria Biomedica
uv.notageneralNo disponible para descarga

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