Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

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dc.contributor.authorMarlevi, David
dc.contributor.authorMariscalā€Harana, Jorge
dc.contributor.authorBurris, Nicholas S.
dc.contributor.authorSotelo, Julio
dc.contributor.authorRuijsink, Bram
dc.contributor.authorHadjicharalambous, Myrianthi
dc.contributor.authorAsner, Liya
dc.contributor.authorSammut, Eva
dc.contributor.authorChabiniok, Radomir
dc.contributor.authorUribe, Sergio
dc.contributor.authorWinter, Reidar
dc.contributor.authorLamata, Pablo
dc.contributor.authorAlastruey, Jordi
dc.contributor.authorNordsletten, David
dc.date.accessioned2022-11-30T02:46:31Z
dc.date.available2022-11-30T02:46:31Z
dc.date.issued2022
dc.description.abstractVentricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol.en_ES
dc.facultadFacultad de IngenierĆ­aen_ES
dc.file.nameMarlevi_Alt2022.pdf
dc.identifier.citationMarlevi, D., Mariscal-Harana, J., Burris, N.S. et al. Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy. J. of Cardiovasc. Trans. Res. 15, 692ā€“707 (2022). https://doi.org/10.1007/s12265-021-10181-1en_ES
dc.identifier.doihttps://doi.org/10.1007/s12265-021-10181-1
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7407
dc.languageen
dc.publisherSpringer
dc.sourceJournal of Cardiovascular Translational Research
dc.subjectDILATED CARDIOMYOPATHYen_ES
dc.subjectAORTIC HEMODYNAMICSen_ES
dc.subjectAORTIC RELATIVE PRESSUREen_ES
dc.subjectAORTIC STIFNESSen_ES
dc.subject4D FOW MRIen_ES
dc.titleAltered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy
dc.typeArticulo
uv.departamentoEscuela de Ingenieria Civil Biomedica

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