Non-invasive local pulse wave velocity using 4D-flow MRI

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dc.contributor.authorMura, JoaquĆ­n
dc.contributor.authorSotelo, Julio
dc.contributor.authorMella, Hernan
dc.contributor.authorWong, James
dc.contributor.authorHussain, Tarique
dc.contributor.authorRuijsink, Bram
dc.contributor.authorUribe, Sergio
dc.date.accessioned2022-11-30T02:46:41Z
dc.date.available2022-11-30T02:46:41Z
dc.date.issued2021
dc.description.abstractPulse Wave Velocity (PWV) corresponds to the velocity at which pressure waves, generated by the systolic contraction in the heart, propagate along the arterial tree. Due to the complex interplay between blood flow and the artery wall, PWV is related to inherent mechanical properties and arterial morphology. PWV has been widely accepted as a biomarker and early predictor to evaluate global arterial distensibility. Still, several local abnormalities often remain hidden or difficult to detect using non-invasive techniques. Here, we introduce a novel method to efficiently construct a local estimate of PWV along the aorta using 4D-Flow MRI data. A geodesic distance map was used to track advancing pulses for efficient flow calculations, based on the observation that the propagation of velocity wavefronts strongly depends on the arterial morphology. This procedure allows us a robust evaluation of the local transit time due to the pulse wave at each position in the aorta. Moreover, the estimation of the local PWV map did not require centerlines, and the final result is projected back to 3D using the same geodesic map. We evaluated PWV values in healthy young and adult volunteers and patients with univentricular physiology after a Fontan procedure. Our method is fast, semi-automatic, and depicts differences between young versus adult volunteers and young volunteers versus Fontan patients, showing consistent results compared to global methods. Remarkably, the technique could detect local differences of PWV on the aortic arch for all subjects, being consistent with previous findings of reduced PWV in the aortic arch.en_ES
dc.facultadFacultad de IngenierĆ­aen_ES
dc.file.nameMura_Non2021.pdf
dc.identifier.doihttps://doi.org/10.1016/j.bspc.2021.103259
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7462
dc.languageen
dc.publisherElsevier
dc.sourceBiomedical Signal Processing and Control
dc.subjectPULSE WAVE VELOCITYen_ES
dc.subjectARTERIAL STIFFNESSen_ES
dc.subjectCARDIAC DISEASESen_ES
dc.subject4D-FLOW MRIen_ES
dc.titleNon-invasive local pulse wave velocity using 4D-flow MRI
dc.typeArticulo
uv.departamentoEscuela de Ingenieria Biomedica
uv.notageneralNo disponible para descarga

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