Comprehensive Assessment of Left Intraventricular Hemodynamics Using a Finite Element Method: An Application to Dilated Cardiomyopathy Patients

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dc.contributor.authorFranco, Pamela
dc.contributor.authorSotelo, Julio
dc.contributor.authorMontalba, Cristian
dc.contributor.authorRuijsink, Bram
dc.contributor.authorKerfoot, Eric
dc.contributor.authorNordsletten, David
dc.contributor.authorMura, JoaquĆ­n
dc.contributor.authorHurtado, Daniel
dc.contributor.authorUribe, Sergio
dc.date.accessioned2022-11-30T02:46:21Z
dc.date.available2022-11-30T02:46:21Z
dc.date.issued2021
dc.description.abstractIn this paper, we applied a method for quantifying several left intraventricular hemodynamic parameters from 4D Flow data and its application in a proof-of-concept study in dilated cardiomyopathy (DCM) patients. In total, 12 healthy volunteers and 13 DCM patients under treatment underwent short-axis cine b-SSFP and 4D Flow MRI. Following 3D segmentation of the left ventricular (LV) cavity and registration of both sequences, several hemodynamic parameters were calculated at peak systole, e-wave, and end-diastole using a finite element approach. Sensitivity, inter- and intra-observer reproducibility of hemodynamic parameters were evaluated by analyzing LV segmentation. A local analysis was performed by dividing the LV cavity into 16 regions. We found significant differences between volunteers and patients in velocity, vorticity, viscous dissipation, energy loss, and kinetic energy at peak systole and e-wave. Furthermore, although five patients showed a recovered ejection fraction after treatment, their hemodynamic parameters remained low. We obtained several hemodynamic parameters with high inter- and intra-observer reproducibility. The sensitivity study revealed that hemodynamic parameters showed a higher accuracy when the segmentation underestimates the LV volumes. Our approach was able to identify abnormal flow patterns in DCM patients compared to volunteers and can be applied to any other cardiovascular diseases.en_ES
dc.facultadFacultad de IngenierĆ­aen_ES
dc.file.nameFranco_Com2021.pdf
dc.identifier.citationFranco, P.; Sotelo, J.; Montalba, C.; Ruijsink, B.; Kerfoot, E.; Nordsletten, D.; Mura, J.; Hurtado, D.; Uribe, S. Comprehensive Assessment of Left Intraventricular Hemodynamics Using a Finite Element Method: An Application to Dilated Cardiomyopathy Patients. Appl. Sci. 2021, 11, 11165. https://doi.org/10.3390/app112311165en_ES
dc.identifier.doihttps://doi.org/10.3390/app112311165
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7331
dc.languageen
dc.publisherMDPI
dc.rightsĀ© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.sourceApplied Sciences
dc.subject4D FLOW MRIen_ES
dc.subjectFLOW QUANTIFICATIONen_ES
dc.subjectFINITE ELEMENTSen_ES
dc.subjectLEFT VENTRICLEen_ES
dc.subjectDILATED CARDIOMYOPATHYen_ES
dc.titleComprehensive Assessment of Left Intraventricular Hemodynamics Using a Finite Element Method: An Application to Dilated Cardiomyopathy Patients
dc.typeArticulo
uv.departamentoEscuela de Ingenieria Biomedica

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