Catalina Moller, AlejandraParra, CarolSaid, BastianWerner, EnriqueFlores, SusanaVillena, JoanRusso, AlessandraCaro, NelsonMontenegro, IvánMadrid, Alejandro2022-11-302022-11-302021Moller, A.C.; Parra, C.; Said,B.; Werner, E.; Flores, S.; Villena, J.;Russo, A.; Caro, N.; Montenegro, I.;Madrid, A.et al. Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Aloysia polystachya Harvested in Central Chile. Molecules 2021, 26, 131. https://doi.org/10.3390/molecules26010131http://repositoriobibliotecas.uv.cl/handle/uvscl/7440The aim of this study was to determine, first, the chemical composition of Aloysia polystachya (Griseb) Moldenke essential oil, from leaves harvested in central Chile; and second, its antioxidant and cytotoxic activity. Eight compounds were identified via gas chromatography–mass spectrometry (GC–MS) analyses, with the most representative being R-carvone (91.03%), R-limonene (4.10%), and dihydrocarvone (1.07%). For Aloysia polystachya essential oil, antioxidant assays (2,2-diphenyl1-picrylhydrazyl (DPPH), H2O2, ferric reducing antioxidant power (FRAP), and total reactive antioxidant potential (TRAP)) showed good antioxidant activity compared to commercial antioxidant controls; and anti-proliferative assays against three human cancer cell lines (colon, HT-29; prostate, PC-3; and breast, MCF-7) determined an IC50 of 5.85, 6.74, and 9.53 μg/mL, and selectivity indices of 4.75, 4.12, and 2.92 for HT-29, PC-3, and MCF-7, respectively. We also report on assays with CCD 841 CoN (colon epithelial). Overall, results from this study may represent, in the near future, developments for natural-based cancer treatments.Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).ALOYSIA POLYSTACHYATERPENOIDSCYTOTOXIC ACTIVITYSELECTIVITY INDEXArticulohttps://doi.org/10.3390/molecules26010131