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Ítem Finanzas Públicas(Ril editores, 2016) Del Barrio Vásquez, DiegoÍtem Taxanes for advanced non-small cell lung cancer (Protocol)(Cochrane, 2018) Madrid, Eva; Barros Monge, Manuel J; Urrútia, Gerard; Roqué I Figuls, Marta; Pérez Bracchiglione, Javier; Vargas Peirano, Manuel; Loézar Hernández, Cristóbal Nicolás; Bonfill Cosp, XavierThis is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of taxanes as part of a combined or single‐agent therapy versus other agents or best supportive care as first‐ or second‐line treatment for advanced non‐small cell lung cancer (NSCLC). A secondary objective is to assess different modes or schemes of administration of taxanes in patients with this disease.Ítem Pre‐ and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption(Wiley, 2019) Plaza, Wladimir; Gaschino, Felice; Gutiérrez, Camilo; Santibañez, Nicolás; Estay‐Olmos, Camila; Sotomayor‐Zárate, Ramón; De la Fuente‐Ortega, Erwin; Pautass, Ricardo M.; Haeger, Paola A.Repeated exposure to alcohol increases retrieval of fear‐conditioned memories, which facilitates, among other factors, the emergence of post‐traumatic stress disorder (PTSD). Individuals with PTSD are more likely to develop alcohol and substance abuse related disorders. We assessed if prenatal and early postnatal alcohol exposure (PAE) increased the susceptibility to retain aversive memories and if this was associated with subsequent heightened alcohol consumption. Pregnant Sprague‐Dawley rats were exposed for 22 hr/day, throughout pregnancy and until postnatal Day 7 to a single bottle of sucralose ‐ sweetened 10% alcohol solution (PAE Group), or to a single bottle of tap water and sucralose (Control Group). Auditory fear conditioning (AFC) was performed in the adolescent offspring at postnatal Day 40. Freezing was measured during acquisition, retention and extinction phases, followed by 3 weeks of free choice alcohol intake. Female, but not male, PAE rats exhibited impaired extinction of the aversive memory, a finding associated with higher levels of 3‐4 Dihidroxyphenylacetic acid (DOPAC) in the nucleus accumbens and heightened alcohol intake, respect to controls. These findings suggest that PAE makes females more vulnerable to long‐term retention of aversive memories, which coexist with heightened alcohol intake. These findings are reminiscent of those of PTSDÍtem Development of Fixed Dose Combination Products Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy(Springer, 2019) Hens, Bart; Corsetti, Maura; Bermejo, Marival; Löbenberg, Raimar; González, Pablo M.; Mitra, V; Desai, Divyakant; Murthy Chilukuri, Dakshina; Aceituno, AlexisThe gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature poses a great challenge for formulation scientists when developing more complex dosage forms such as those combining two or more drugs. Fixed dose combination (FDC) products are two or more single active ingredients combined in a single dosage form. This formulation strategy represents a novel formulation which is as safe and effective compared to every mono-product separately. A complex drug product, to be dosed through a complex route, requires judicious considerations for formulation development. Additionally, it represents a challenge from a regulatory perspective at the time of demonstrating bioequivalence (BE) for generic versions of such drug products. This report gives the reader a summary of a 2-day short course that took place on the third and fourth of November at the Annual Association of Pharmaceutical Scientists (AAPS) meeting in 2018 at Washington, D.C. This manuscript will offer a comprehensive view of the most influential aspects of the GI physiology on the absorption of drugs and current techniques to help understand the fate of orally ingested drug products in the complex environment represented by the GI tract. Through case studies on FDC product development and regulatory issues, this manuscript will provide a great opportunity for readers to explore avenues for successfully developing FDC products and their generic versions.Ítem Inclusión de salud basada en evidencia en carreras de la salud en Chile y el modelo integrado Metodología de la Investigación Científica-Medicina Basada en Evidencia en la Universidad de Valparaíso(Elsevier, 2019) Papuzinski, Cristian; Loézar, Cristóbal; Carvajal, Natalia; Vargas, Manuel; Borgeat, Marjorie; Madrid, Eva; Pérez-Bracchiglione, Javier; Arancibia, MarceloIntroducción: La salud basada en evidencia (SBE) integra el uso de la mejor evidencia, la experiencia clínica y los valores y preferencias del paciente para la toma de decisiones. Su incorporación en las carreras sanitarias de Chile es desconocida. Métodos: Se realizó un estudio de corte transversal para evaluar la incorporación de SBE en los programas de las carreras sanitarias en Chile hasta 2019. Se describe la integración del modelo Metodología de la Investigación Científica (MIC)-Medicina Basada en la Evidencia (MBE) en la Escuela de Medicina de la Universidad de Valparaíso. Resultados: Un total de 49 universidades imparten carreras sanitarias. Un 8,13% incorpora SBE como asignatura explícitamente. Todas incorporan asignaturas que potencialmente incluyen contenidos de SBE. Las carreras de Medicina y Enfermería son las que más incorporan SBE, pero solo una carrera de Medicina incluye SBE como asignatura por más de un semestre. El modelo integrado MIC/MBE (4 semestres), orientado en competencias y centrado en el alumno, involucra el diseno ̃ y ejecución de un protocolo de investigación, así como el análisis crítico de la mejor evidencia, integrado con los valores de los pacientes. Conclusión: La incorporación de SBE como asignatura es muy infrecuente en carreras sanitarias chilenas. Se enfatiza su inclusión transdisciplinaria como asignatura individual desde un modelo que integre la ensenanza ̃ de MIC, sobre todo en universidades estatales.Ítem Study of the Nucleation and Growth Mechanisms of Copper Electrodeposition on Bare and Nitrogen-Doped Reduced Graphene Oxide Modified SnO2:F/glass Substrates(The Electrochemical Society, 2020) Riveros, G.; León, M.; Ramírez, D.; Hernández, L.; Martín, F.; Romero, R.; Dalchiele, Enrique A.In this article, the influence of a nitrogen-doped electrochemically reduced graphene oxide layer on the nucleation and growth mechanisms of copper electrodeposition was studied. Thus, copper electrodeposition from an acidic solution was evaluated using two different substrates: fluorine-doped tin oxide (FTO), and fluorine-doped tin oxide covered with a nitrogen-doped reduced graphene oxide layer (FTO/N-ERGO). In both cases, chronoamperometric curves were obtained, which were analyzed and deconvoluted using pre-established models and equations, where the different contribution and nucleation parameters were determined. Field emission scanning electron microscopy (FESEM) images were acquired in order to observe the morphology and verify the nuclei density for each case considered in this study. In the case of copper electrodeposition onto FTO, an instantaneous three-dimensional nucleation was observed, together with a proton reduction reaction. When FTO/N-ERGO was used as a substrate, a new instantaneous two-dimensional nucleation process was observed in addition to the processes previously described. Furthermore, the increased density of active sites and the changes in copper morphology are directly related with the N-ERGO layer, which also increased the kinetic constant for the proton reduction reaction and the nucleation rate per active site during the copper electrodeposition process.Ítem Polis en conflicto: memoria urbana del Golpe de Estado de septiembre de 1973 en Valparaíso, Chile(Centro de Investigaciones Geográficas, 2020) Castañeda Meneses, Patricia; Cazorla Becerra, Ketty; Cuevas Lang, KatherineEn Chile, el 11 de septiembre de 1973 se produce un Golpe de Estado que inicia una dictadura cívico militar que se extendió hasta marzo de 1990. El presente trabajo tiene por objetivo rescatar la memoria urbana de la población mayor de Valparaíso respecto del desarrollo del Golpe de Estado en la ciudad. Se realizó un trabajo de campo aplicando 32 entrevistas cualitativas de enfoque biográfico. Los resultados indican que la memoria de la ciudad reconoce en el Golpe de Estado un hito que fracturó la polis a través de la ruptura del espacio político ciudadano debido a la intervención militar. Como consecuencia, las relaciones entre el Estado y la ciudadanía quedaron retenidas dentro de un marco dictatorial de 17 años, aportando un complejo legado de confrontación urbana definida desde el conflicto y la hostilidad.Ítem Screening de Lesiones Orales Malignas y Potencialmente Malignas en Funcionarios de Universidad de Valparaíso y Universidad Viña del Mar Durante los Años 2016 - 2017(Universidad de La Frontera, 2020) Cordero, Karina; Torres, Coral; Anabalón, Paula; Fernández, María José; Suzarte, Josefina; Wu, KaiEl objetivo de este estudio es determinar la prevalencia de lesiones orales malignas y potencialmente malignas (LPM) en funcionarios de la Universidad de Valparaíso y de Viña del Mar durante los años 2016 - 2017. Fueron citados 161 funcionarios, quienes accedieron a una encuesta que evaluaba factores de riesgo de cáncer oral (tabaco y alcohol) y si habían escuchado de la patología, sumado a un examen clínico. De los pacientes examinados, se diagnosticaron 121 lesiones de las cuales 2 fueron diagnosticadas como lesiones potencialmente malignas: Liquen plano y Leucoplasia, con una prevalencia de 1,7 %. El 50,3 % de los pacientes sabía de la existencia de cáncer oral. El Screening es una medida que permite dar a conocer a la población la existencia de cáncer oral y alertarlos sobre la importancia de su examen para su identificación de manera temprana.Ítem Dust trapping around Lagrangian points in protoplanetary disks(European Southern Observatory, 2020) Montesinos, Matías; Olofsson, Johan; Bayo, Amelia; Sucerquia, MarioAims. Trojans are defined as objects that share the orbit of a planet at the stable Lagrangian points L4 and L5. In the Solar System, these bodies show a broad size distribution ranging from micrometer (μm) to centimeter (cm) particles (Trojan dust) and up to kilometer (km) rocks (Trojan asteroids). It has also been theorized that earth-like Trojans may be formed in extra-solar systems. The Trojan formation mechanism is still under debate, especially theories involving the effects of dissipative forces from a viscous gaseous environment. Methods. We perform hydro-simulations to follow the evolution of a protoplanetary disk with an embedded 1–10 Jupiter-mass planet. On top of the gaseous disk, we set a distribution of μm–cm dust particles interacting with the gas. This allows us to follow dust dynamics as solids get trapped around the Lagrangian points of the planet. Results. We show that large vortices generated at the Lagrangian points are responsible for dust accumulation, where the leading Lagrangian point L4 traps a larger amount of submillimeter (submm) particles than the trailing L5, which traps mostly mm–cm particles. However, the total bulk mass, with typical values of ~Mmoon, is more significant in L5 than in L4, in contrast to what is observed in the current Solar System a few gigayears later. Furthermore, the migration of the planet does not seem to affect the reported asymmetry between L4 and L5. Conclusions. The main initial mass reservoir for Trojan dust lies in the same co-orbital path of the planet, while dust migrating from the outer region (due to drag) contributes very little to its final mass, imposing strong mass constraints for the in situ formation scenario of Trojan planets.Ítem ¿Qué tecnología escojo para mi clase? Percepción de estudiantes de medicina sobre clickers y Kahoot(Fundación Educación Médica, 2020) Guerra Zuñiga, Maria; Cuevas Lang, Katherine; Segovia Chamorro, JaimeIntroducción: Las nuevas generaciones de estudiantes y las distintas problemáticas de las asignaturas instan a modificar las actividades formativas hacia nuevas formas utilizando tecnologías de la información y la comunicación. Objetivo: Identificar la opinión de los alumnos de primer y segundo año de la carrera de medicina, Universidad de Valparaíso, respecto del uso de un sistema inalámbrico de respuesta (clicker) y Kahoot en el aula. Sujetos y métodos: Estudio cualitativo, fenomenológico. Para la producción de información se realizaron 2 grupos focales con un total de 18 participantes, los cuales se transcribieron según el principio de verbatim. El análisis utilizado fue de contenido. Se efectuó triangulación de la información con técnica de investigadores. Resultados: El uso de clickersy Kahoot se ha valorado positivamente. Se produjo información acerca de las ventajas e inconvenientes de cada una de las tecnologías. Ambas logran focalizar la atención de los estudiantes y aumentan su sensación de disfrute, aprendizaje y calidad de vida al ser estrategias de gamificación. Conclusión: Ambas estrategias tienen la potencialidad de modificar favorablemente los ambientes del aula, con ventajas y limitaciones que deben ser conocidas por los docentes. Es relevante insertarlas dentro de estrategias educativas coherentes para potenciar los procesos de enseñanza-aprendizaje.Ítem KPSI como herramienta de autoevaluación metacognitiva en el desarrollo de la competencia intercultural en salud en medicina(Universidad de Tarapacá. Facultad de Ciencias de la Salud, 2020) Guerra-Zúñiga, María; Segovia-Chamorro, JaimeLa autoevaluación es necesaria para el aprendizaje efectivo, mejorar la autoeficacia, y el desempeño académico. Dentro de los instrumentos de autoevaluación existe el Knowledge and Prior Study Inventory (KPSI) con cualidades metacognitivas. El objetivo de este trabajo fue examinar los resultados de la aplicación de KPSI en un curso de Interculturalidad y Salud y recoger la percepción de estudiantes respecto a su uso en medicina. Este fue un trabajo de naturaleza mixta. La etapa cuantitativa evaluó los puntajes del instrumento autoaplicado al inicio y al final de la asignatura, arrojando el delta promedio del curso. La etapa cualitativa exploró las percepciones del uso y utilidad en el aprendizaje del instrumento. Se realizaron dos grupos focales, se transcribieron los audios siguiendo el principio de verbatim. Se realizó análisis de contenido. La participación voluntaria y anónima. El puntaje promedio del test al inicio del curso fue de 1,7 puntos elevándose a 3,6 durante la segunda aplicación. Las preguntas con menor puntaje diferencial consideran contenidos integrados en asignaturas previas al curso, mientras que las preguntas con mayor puntaje diferencial estaban integradas por contenidos de aporte exclusivo de la asignatura. Los resultados cualitativos son claramente positivos en la percepción de aprendizaje, ayuda a identificar las fortalezas y debilidades individuales durante el proceso de aprender. Por otro lado, los invita a hacer evidente la metacognición, vale decir, cuestionarse el propio proceso de aprendizaje y lo difícil que son los procesos evaluativos en general. Las autoevaluaciones formativas con enfoque metacognitivo son positivas para el aprendizaje y se recomienda su incorporación en carreras de la salud. Es fundamental para el trabajo en el sistema de salud con la diversidad cultural de Chile que médicos desarrollen la competencia intercultural propiciada a través de la metacognición.Ítem International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth(Wiley, 2020) Flores, Marie ThereseAvulsion of permanent teeth is one of the most serious dental injuries. Prompt and correct emergency management is essential for attaining the best outcome after this injury. The International Association of Dental Traumatology (IADT) has developed these Guidelines as a consensus statement after a comprehensive review of the dental literature and working group discussions. It represents the current best evidence and practice based on that literature search and expert opinions. Experienced researchers and clinicians from various specialties and the general dentistry community were included in the working group. In cases where the published data did not appear conclusive, recommendations were based on consensus opinions or majority decisions of the working group. They were then reviewed and approved by the members of the IADT Board of Directors. The purpose of these Guidelines is to provide clinicians with the most widely accepted and scientifically plausible approaches for the immediate or urgent care of avulsed permanent teeth. The IADT does not, and cannot, guarantee favorable outcomes from adherence to the Guidelines. However, the IADT believes that their application can maximize the probability of favorable outcomes.Ítem An extension of the method of brackets. Part 2(De Gruyter, 2020) Gonzalez, Ivan; Jiu, Lin; Moll, Victor H.The method of brackets, developed in the context of evaluation of integrals coming from Feynman diagrams, is a procedure to evaluate definite integrals over the half-line. This method consists of a small number of operational rules devoted to convert the integral into a bracket series. A second small set of rules evaluates this bracket series and produces the result as a regular series. The work presented here combines this method with the classical Mellin transform to extend the class of integrands where the method of brackets can be applied. A selected number of examples are used to illustrate this procedure.Ítem Thermodynamic Formalism in Neuronal Dynamics and Spike Train Statistics(MDPI, 2020) Cofré, RodrigoThe Thermodynamic Formalism provides a rigorous mathematical framework for studying quantitative and qualitative aspects of dynamical systems. At its core, there is a variational principle that corresponds, in its simplest form, to the Maximum Entropy principle. It is used as a statistical inference procedure to represent, by specific probability measures (Gibbs measures), the collective behaviour of complex systems. This framework has found applications in different domains of science. In particular, it has been fruitful and influential in neurosciences. In this article, we review how the Thermodynamic Formalism can be exploited in the field of theoretical neuroscience, as a conceptual and operational tool, in order to link the dynamics of interacting neurons and the statistics of action potentials from either experimental data or mathematical models. We comment on perspectives and open problems in theoretical neuroscience that could be addressed within this formalismÍtem Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines(MDPI, 2020) Weinstein, CarolineGlobe artichoke (Cynara scolymus L.) is considered one of the most significant sources of phenolic antioxidants in nature. However, more than 60% of its total volume is discarded for consumption purposes, making available an abundant, inexpensive and profitable source of natural antioxidants in the discarded fractions. Polyphenolic antioxidants from a South American variety of artichoke agro-industrial discards (external bracts and stems) were obtained by mild extraction processes. Best results were achieved at 40 °C, 75% of ethanol and 10 min of reaction, obtaining 2.16 g gallic acid equivalent (GAE)/100 g of total phenolic compounds (TPC) and 55,472.34 µmol Trolox equivalent (TE)/100 g of antioxidant capacity (oxygen radical absorbance capacity (ORAC)). High-performance liquid chromatography (HPLC) analyses determined that caffeoylquinic acids comprise up to 85% of the total polyphenolic content, and only around 5% are flavonoids. Inulin content in the artichokes residues was recovered (48.4% dry weight (dw)), resulting in an extract with 28% of inulin in addition to the aforementioned antioxidant capacity. The artichoke discard extract in a concentration of 500 mg/L produced a strong decrease in Caco-2 and MCF-7 cancer cell lines viability, whereas healthy fibroblasts maintained their viability when the extract was concentrated at 1500 mg/L. These results suggest that the artichoke extract presents a good anti-proliferative potential effect on Caco-2 and MCF-7 cells.Ítem Evidencia científica sobre cuidados de Enfermería y COVID-19(Ecimed, 2020) Guerrero-Nancuante, Camilo; Armstrong-Barea, Lucy; González-Adonis1, FranciscaIntroducción: COVID-19 ha generado efectos negativos en gran parte del mundo. Su rápida propagación produjo la necesidad de investigar respecto a los cuidados de enfermería otorgados a las comunidades en el contexto de pandemia de SARS CoV2. Objetivo: analizar la evidencia científica disponible respecto a cuidados de enfermería y COVID-19. Métodos: Se realizó una revisión de alcance mediante el marco metodológico de PRISMA-ScR, en bases de datos científicas EMBASE, Scopus, PubMed, Web of Science y otras fuentes de consulta para articulo publicados en inglés entre 1 de diciembre 2019 al 27 de junio 2020. Se analizó fecha de publicación, país de origen y género del primer autor, tipo de artículo y dimensión o tópico de la investigación. Se incluyeron en total 205 artículos. Conclusiones: El 55,61% correspondió a investigaciones realizadas por mujeres como primera autora; el 37,56% de los estudios analizados fueron desarrollados en Estados Unidos. El 68,78% de los manuscritos corresponden a editoriales, comentarios/reflexiones, revisiones e investigaciones primarias. El 63,91% de las publicaciones se relacionaron a tópicos de prácticas de enfermería, rol profesional, salud mental y adultez mayor. Existen baja diversificación temática de los estudios asociados a cuidados de enfermería y COVID-19, como también investigaciones que permitan evaluar las intervenciones disciplinares en el actual contexto. Urge mayor participación femenina en los estudios en dicho ámbito, además de proyectar investigaciones en otras poblaciones vulnerables.Ítem The ALPINE-ALMA [CII] survey: Small Lya-[CII] velocity offsets in main-sequence galaxies at 4.4 < z < 6(European Southern Observatory, 2020) Ibar, Eduardo; Mendez Hernandez, HugoContext. The Lyman- line in the ultraviolet (UV) and the [CII] line in the far-infrared (FIR) are widely used tools to identify galaxies in the early Universe and to obtain insights into interstellar medium (ISM) properties in high-redshift galaxies. By combining data obtained with ALMA in band 7 at 320 GHz as part of the ALMA Large Program to INvestigate [CII] at Early Times (ALPINE) with spectroscopic data from DEIMOS at the Keck Observatory, VIMOS and FORS2 at the Very Large Telescope, we assembled a unique sample of 53 main-sequence star-forming galaxies at 4:4 < z < 6 in which we detect both the Lyman- line in the UV and the [CII] line in the FIR. Aims. The goal of this paper is to constrain the properties of the Ly emission in these galaxies in relation to other properties of the ISM. Methods. We used [CII], observed with ALMA, as a tracer of the systemic velocity of the galaxies, and we exploited the available optical spectroscopy to obtain the Ly -[CII] and ISM-[CII] velocity offsets. Results. We find that 90% of the selected objects have Ly -[CII] velocity offsets in the range 0 < vLy �����[CII] < 400 km s�����1, in line with the few measurements available so far in the early Universe, and significantly smaller than those observed at lower redshifts. At the same time, we observe ISM-[CII] offsets in the range �����500 < vISM�����[CII] < 0 km s�����1, in line with values at all redshifts, which we interpret as evidence for outflows in these galaxies. We find significant anticorrelations between vLy �����[CII] and the Ly rest-frame equivalent width EW0(Ly ) (or equivalently, the Ly escape fraction fesc(Ly )): galaxies that show smaller vLy �����[CII] have larger EW0(Ly ) and fesc(Ly ). Conclusions. We interpret these results in the framework of available models for the radiative transfer of Ly photons. According to the models, the escape of Ly photons would be favored in galaxies with high outflow velocities, producing large EW0(Ly ) and small vLy �����[CII], in agreement with our observations. The uniform shell model would also predict that the Ly escape in galaxies with slow outflows (0 < vout < 300 km s�����1) is mainly determined by the neutral hydrogen column density (NHI) along the line of sight, while the alternative model by Steidel et al. (2010) would more highly favor a combination of NHI at the systemic velocity and covering fraction as driver of the Ly escape. We suggest that the observed increase in Ly escape that is observed in the literature between z 2 and z 6 is not due to a higher incidence of fast outflows at high redshift, but rather to a decrease in average NHI along the line of sight, or alternatively, a decrease in HI covering fractionÍtem The Gaia-ESO Survey: detection and characterisation of single-line spectroscopic binaries(European Southern Observatory, 2020) Bayo, AmeliaContext. Multiple stellar systems play a fundamental role in the formation and evolution of stellar populations in galaxies. Recent and ongoing large ground-based multi-object spectroscopic surveys significantly increase the sample of spectroscopic binaries (SBs) allowing analyses of their statistical properties. Aims. We investigate the repeated spectral observations of the Gaia-ESO Survey internal data release 5 (GES iDR5) to identify and characterise SBs with one visible component (SB1s) in fields covering mainly the discs, the bulge, the CoRot fields, and some stellar clusters and associations. Methods. A statistical χ2-test is performed on spectra of the iDR5 subsample of approximately 43 500 stars characterised by at least two observations and a signal-to-noise ratio larger than three. In the GES iDR5, most stars have four observations generally split into two epochs. A careful estimation of the radial velocity (RV) uncertainties is performed. Our sample of RV variables is cleaned from contamination by pulsation- and/or convection-induced variables using Gaia DR2 parallaxes and photometry. Monte-Carlo simulations using the SB9 catalogue of spectroscopic orbits allow to estimate our detection efficiency and to correct the SB1 rate to evaluate the GES SB1 binary fraction and its relation to effective temperature and metallicity. Results. We find 641 (resp., 803) FGK SB1 candidates at the 5σ (resp., 3σ) level. The maximum RV differences range from 2.2 km s−1 at the 5σ confidence level (1.6 km s−1 at 3σ) to 133 km s−1 (in both cases). Among them a quarter of the primaries are giant stars and can be located as far as 10 kpc. The orbital-period distribution is estimated from the RV standard-deviation distribution and reveals that the detected SB1s probe binaries with log P[d] ⪅ 4. We show that SB1s with dwarf primaries tend to have shorter orbital periods than SB1s with giant primaries. This is consistent with binary interactions removing shorter period systems as the primary ascends the red giant branch. For two systems, tentative orbital solutions with periods of 4 and 6 d are provided. After correcting for detection efficiency, selection biases, and the present-day mass function, we estimate the global GES SB1 fraction to be in the range 7–14% with a typical uncertainty of 4%. A small increase of the SB1 frequency is observed from K- towards F-type stars, in agreement with previous studies. The GES SB1 frequency decreases with metallicity at a rate of (−9 ± 3)% dex−1 in the metallicity range −2.7 ≤ [Fe/H] ≤ +0.6. This anticorrelation is obtained with a confidence level higher than 93% on a homogeneous sample covering spectral types FGK and a large range of metallicities. When the present-day mass function is accounted for, this rate turns to (−4 ± 2)% dex−1 with a confidence level higher than 88%. In addition we provide the variation of the SB1 fraction with metallicity separately for F, G, and K spectral types, as well as for dwarf and giant primaries.Ítem The Gaia–ESO Survey: Carbon Abundance in the Galactic Thin and Thick Disks(The American Astronomical Society, 2020) Bayo, AmeliaThis paper focuses on carbon, which is one of the most abundant elements in the universe and is of high importance in the field of nucleosynthesis and galactic and stellar evolution. The origin of carbon and the relative importance of massive and low- to intermediate-mass stars in producing it is still a matter of debate. We aim at better understanding the origin of carbon by studying the trends of [C/H], [C/Fe], and [C/Mg] versus [Fe/H] and [Mg/H] for 2133 FGK dwarf stars from the fifth Gaia–ESO Survey internal data release (GES iDR5). The availability of accurate parallaxes and proper motions from Gaia DR2 and radial velocities from GES iDR5 allows us to compute Galactic velocities, orbits, absolute magnitudes, and, for 1751 stars, Bayesian-derived ages. Three different selection methodologies have been adopted to discriminate between thin- and thick-disk stars. In all the cases, the two stellar groups show different [C/H], [C/Fe], and [C/Mg] and span different age intervals, with the thick-disk stars being, on average, older than the thin-disk ones. The behaviors of [C/H], [C/Fe], and [C/Mg] versus [Fe/H], [Mg/H], and age all suggest that C is primarily produced in massive stars. The increase of [C/Mg] for young thin-disk stars indicates a contribution from low-mass stars or the increased C production from massive stars at high metallicities due to the enhanced mass loss. The analysis of the orbital parameters Rmed and ∣Zmax∣ supports an “inside–out” and “upside–down” formation scenario for the disks of the Milky Way.Ítem Bodily distribution of projectile injuries in Chilean protests(Elsevier, 2020) Cox, Pablo; Riveros, Rodrigo; Leiva, Camila; Carvajal, Yuri; Fuentes, Pablo; Recasens, Jaime; Covarrubias, Alvaro; Torres, Francisco; Ramírez, Daniel; Verdugo, Marcelo; Muñoz, Pablo