Gliotransmission: A Novel Target for the Development of Antiseizure Drugs

Fecha

2020

Profesor Guía

Formato del documento

Articulo

ORCID Autor

Título de la revista

ISSN de la revista

Título del volumen

Editor

Sage

Ubicación

ISBN

ISSN

item.page.issne

Facultad

Facultad de Ciencias

Departamento o Escuela

Instituto de Fisiologia

Determinador

Recolector

Especie

Nota general

Resumen

For more than a century, epilepsy has remained an incapacitating neurological disorder with a high incidence worldwide. Mesial temporal lobe epilepsy (TLE) is a common type of epilepsy without an effective pharmacological treatment. An increase in excitability and hypersynchrony of electrical neuronal activity during development are typically associated with an excitatory/inhibitory imbalance in the neuronal network. Astrocytes release gliotransmitters, which can regulate neuronal excitability and synaptic transmission; therefore, the classical neurocentric vision of the cellular basis of epileptogenesis has begun to change. Growing evidence suggests that the key contribution of astrocyte-toneuron signaling in the mechanisms underlies the initiation, propagation, and recurrence of seizure activity. The aim of this review was to summarize current evidence obtained from experimental models that suggest how alterations in astroglial modulation of synaptic transmission and neuronal activity contribute to the development of this brain disease. In this article, we will summarize the main pharmacological, Ca2+-imaging, and electrophysiological findings in the gliotransmitter-mediated modulation of neuronal activity and their possible regulation as a novel cellular target for the development of pharmacological strategies for treating refractory epilepsies.

Descripción

Lugar de Publicación

Auspiciador

Palabras clave

GLIOTRANSMISSION, DRUG-RESISTANT EPILEPSY, PURINERGIC RECEPTORS, GLUTAMATERGIC RECEPTORS, PHARMACOLOGICAL TARGETS, CHRONIC EPILEPSY MODELS, ATP

Licencia

© The Author(s) 2020

URL Licencia