Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells
Date
2021
item.contributor.advisor
item.page.type
Articulo
item.page.orcidurl
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers
item.page.ubicacion
item.page.isbn
item.page.issn
item.page.issne
item.page.doiurl
item.page.dc.facultad
Facultad de Ciencias
item.page.uv.departamento
Centro Interdisciplinario de Neurociencia de Valparaiso
item.page.uv.especie.determinador
item.page.uv.especie.recolector
item.page.uv.especie
item.page.uv.notageneral
Abstract
The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.
Description
item.page.coverage.spatial
item.page.sponsorship
Keywords
CELL COMMUNICATION, LEUKOCYTES, CANCER, INFLAMMATION, CA2+ SIGNALING, AMOEBOID MIGRATION, MESENCHYMAL MIGRATION, MECHANOTRANSDUCTION