Alzheimer’s Disease, Neural Plasticity and Functional Recovery

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dc.contributor.authorMercerón-Martínez, Daymara
dc.contributor.authorIbaceta-González, Cristobal
dc.contributor.authorSalazar, Claudia
dc.contributor.authorAlmaguer-Melian, William
dc.contributor.authorBergado-Rosado, Jorge A.
dc.contributor.authorPalacios, Adrian G.
dc.date.accessioned2022-11-30T02:46:34Z
dc.date.available2022-11-30T02:46:34Z
dc.date.issued2021
dc.description.abstractAlzheimer’s disease (AD) is the most common and devastating neurodegenerative condition worldwide, characterized by the aggregation of amyloid-β and phosphorylated tau protein, and is accompanied by a progressive loss of learning and memory. A healthy nervous system is endowed with synaptic plasticity, among others neural plasticity mechanisms, allowing structural and physiological adaptations to changes in the environment. This neural plasticity modification sustains learning and memory, and behavioral changes and is severely affected by pathological and aging conditions, leading to cognitive deterioration. This article reviews critical aspects of AD neurodegeneration as well as therapeutic approaches that restore neural plasticity to provide functional recoveries, including environmental enrichment, physical exercise, transcranial stimulation, neurotrophin involvement, and direct electrical stimulation of the amygdala. In addition, we report recent behavioral results in Octodon degus, a promising natural model for the study of AD that naturally reproduces the neuropathological alterations observed in AD patients during normal aging, including neuronal toxicity, deterioration of neural plasticity, and the decline of learning and memory.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameMerceron_Alz2021.pdf
dc.identifier.citationMercerón-Martínez, Daymara et al. ‘Alzheimer’s Disease, Neural Plasticity, and Functional Recovery’. 1 Jan. 2021 : S37 – S50.en_ES
dc.identifier.doi10.3233/JAD-201178
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7425
dc.languageen
dc.publisherIop Press
dc.sourceJournal of Alzheimer's Disease
dc.subjectNEURAL PLASTICITYen_ES
dc.subjectNEURORESTAURATIONen_ES
dc.subjectNON-TRANSGENIC ANIMAL MODELS OF NEURODEGENERATIONen_ES
dc.titleAlzheimer’s Disease, Neural Plasticity and Functional Recovery
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso
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