Maternal and perinatal outcomes related to COVID-19 and pregnancy: An overview of systematic reviews

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dc.contributor.authorVergara-Merino, Laura
dc.contributor.authorMeza, Nicolás
dc.contributor.authorCouve-Pérez, Constanza
dc.contributor.authorCarrasco, Cynthia
dc.contributor.authorOrtiz-Muñoz, Luis
dc.contributor.authorMadrid, Eva
dc.contributor.authorBohorquez-Blanco, Sandra
dc.contributor.authorPérez-Bracchiglione, Javier
dc.date.accessioned2022-11-30T02:47:06Z
dc.date.available2022-11-30T02:47:06Z
dc.date.issued2021
dc.description.abstractIntroduction: Evidence about coronavirus disease 2019 (COVID-19) and pregnancy has rapidly increased since December 2019, making it difficult to make rigorous evidence-based decisions. The objective of this overview of systematic reviews is to conduct a comprehensive analysis of the current evidence on prognosis of COVID-19 in pregnant women. Material and methods: We used the Living OVerview of Evidence (L·OVE) platform for COVID-19, which continually retrieves studies from 46 data sources (including PubMed/MEDLINE, Embase, other electronic databases, clinical trials registries, and preprint repositories, among other sources relevant to COVID-19), mapping them into PICO (population, intervention, control, and outcomes) questions. The search covered the period from the inception date of each database to 13 September 2020. We included systematic reviews assessing outcomes of pregnant women with COVID-19 and/or their newborns. Two authors independently screened the titles and abstracts, assessed full texts to select the studies that met the inclusion criteria, extracted data, and appraised the risk of bias of each included systematic review. We measured the overlap of primary studies included among the selected systematic reviews by building a matrix of evidence, calculating the corrected covered area, and assessing the level of overlap for every pair of systematic reviews. Results: Our search yielded 1132 references. 52 systematic reviews met inclusion criteria and were included in this overview. Only one review had a low risk of bias, three had an unclear risk of bias, and 48 had a high risk of bias. Most of the included reviews were highly overlapped among each other. In the included reviews, rates of maternal death varied from 0% to 11.1%, admission to intensive care from 2.1% to 28.5%, preterm deliveries before 37 weeks from 14.3% to 61.2%, and cesarean delivery from 48.3% to 100%. Regarding neonatal outcomes, neonatal death varied from 0% to 11.7% and the estimated infection status of the newborn varied between 0% and 11.5%. Conclusions: Only one of 52 systematic reviews had a low risk of bias. Results were heterogeneous and the overlap of primary studies was frequently very high between pairs of systematic reviews. High-quality evidence syntheses of comparative studies are needed to guide future clinical decisions.en_ES
dc.facultadFacultad de Medicinaen_ES
dc.file.nameVergara_Mate2021.pdf
dc.identifier.citationVergara-Merino L, Meza N, Couve-Pérez C, et al. Maternal and perinatal outcomes related to COVID-19 and pregnancy: An overview of systematic reviews. Acta Obstet Gynecol Scand. 2021;100(7):1200-1218. doi:10.1111/aogs.14118en_ES
dc.identifier.doi10.1111/aogs.14118
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7575
dc.languageen
dc.publisherWiley
dc.sourceActa obstetricia et gynecologica Scandinavica
dc.subjectCORONAVIRUS DISEASE 2019en_ES
dc.subjectCORONAVIRUS INFECTIONSen_ES
dc.subjectINFANTen_ES
dc.subjectNEWBORNen_ES
dc.subjectOVERVIEWen_ES
dc.subjectPREGNANT WOMENen_ES
dc.subjectSYSTEMATIC REVIEWS AS TOPICen_ES
dc.titleMaternal and perinatal outcomes related to COVID-19 and pregnancy: An overview of systematic reviews
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Estudios en Salud (CIESAL)

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