Left Ventricular Global Function Index and the Impact of its Companion Metric

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dc.contributor.authorDiaz-Navarro, Rienzi A.
dc.contributor.authorKerkhof, Peter L.M.
dc.date.accessioned2022-11-30T02:46:51Z
dc.date.available2022-11-30T02:46:51Z
dc.date.issued2021
dc.description.abstractLeft ventricular (LV) global function index (LVGFI) has been introduced as a volume-based composite metric for evaluation of ventricular function. The definition formula combines stroke volume (SV), endsystolic volume (ESV), end-diastolic volume (EDV) and LV mass/density. Being a dimensionless ratio, this new metric has serious limitations which require evaluation at a mathematical and clinical level. Using CMRI in 96 patients we studied LV volumes, various derived metrics and global longitudinal strain (GLS) in order to further characterize LVGFI in three diagnostic groups: acute myocarditis, takotsubo cardiomyopathy and acute myocardial infarction. We also considered the LVGFI companion (C), derived from the quadratic mean. Additional metrics such as ejection fraction (EF), myocardial contraction fraction (MCF) and ventriculo-arterial coupling (VAC), along with their companions (MCFC and VACC) were calculated. All companion metrics (EFC, LVGFIC, MCFC, and VACC) showed sex-specific differences, not clearly reflected by the corresponding ratio-based metrics. LVGFI is mathematically coupled to both EF (with R = 0.86) and VAC (R = 0.87), which observation clarifies why these metrics not only share similar prognostic values but also identical shortcomings. We found that the newly introduced LVGFIC has incremental value compared to the single use of LVGFI, EF, or GLS, when characterizing the three patient groups.en_ES
dc.facultadFacultad de Medicinaen_ES
dc.file.nameRienzi_Left2021.pdf
dc.identifier.citationDiaz-Navarro RA and Kerkhof PLM (2021) Left Ventricular Global Function Index and the Impact of its Companion Metric. Front. Cardiovasc. Med. 8:695883. doi: 10.3389/fcvm.2021.695883en_ES
dc.identifier.doi10.3389/fcvm.2021.695883
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7510
dc.languageen
dc.publisherFrontiers
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
dc.sourceFrontiers in cardiovascular medicine
dc.subjectEJECTION FRACTIONen_ES
dc.subjectEND-SYSTOLIC VOLUMEen_ES
dc.subjectGLOBAL FUNCTION INDEXen_ES
dc.subjectLEFT VENTRICULAR MASSen_ES
dc.subjectRATIO-BASED METRICen_ES
dc.subjectRATIOLOGYen_ES
dc.subjectSTROKE VOLUMEen_ES
dc.subjectVENTRICULO-ARTERIAL COUPLINGen_ES
dc.titleLeft Ventricular Global Function Index and the Impact of its Companion Metric
dc.typeArticulo
uv.departamentoDepartment of Internal Medicine

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