Receptors involved in dexketoprofen analgesia in murine visceral pain

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dc.contributor.authorNoriega, Viviana
dc.contributor.authorSierralta, Fernando
dc.contributor.authorPoblete, P.
dc.contributor.authorAranda, N.
dc.contributor.authorSotomayor-Zárate, Ramón
dc.contributor.authorPrieto, Juan Carlos
dc.contributor.authorMiranda, H. F.
dc.date.accessioned2022-03-08T20:35:55Z
dc.date.available2022-03-08T20:35:55Z
dc.date.issued2020-07-02
dc.description.abstractVarious animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs that produce analgesia have been studied and there is evidence among which NSAIDs deserve to be highlighted. Dexketoprofen (DEX) provides a broad antinociceptive profile in different types of pain; therefore, this study was designed to evaluate the profile of antinociceptive potency in mice. Analgesic activity was evaluated using the acetic acid abdominal constriction test (writhing test), a chemical model of visceral pain. Dose-response curves for i.p. DEX administration (1, 3, 10, 30 and 100 mg/kg), using at least six mice in each of at least five doses, was obtained before and 30 min after pre-treatment with different pharmacological agents. Pretreatment of the mice with opioid receptor antagonists was not effective; however, the serotonin receptor antagonist and nitric oxide synthase inhibitor produce a significant increase in DEX-induced antinociception. The data from the present study shows that DEX produces antinociception in the chemical twisting test of mice, which is explained with difficulty by the simple inhibition of COX. This effect appears to be mediated by other mechanisms in which the contribution of the NO and 5-HT pathways has an important effect on DEXinduced antinociception.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.identifier.doi10.1007/s12038-020-00064-z
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/3797
dc.language.isoenen_ES
dc.publisherIndian Academy of Sciencesen_ES
dc.rights© Indian Academy of Sciencesen_ES
dc.sourceJournal of Biosciencesen_ES
dc.subjectDEXKETOPROFENen_ES
dc.subjectRECEPTOR ANTAGONISTSen_ES
dc.subjectVISCERALen_ES
dc.subjectWRITHING TESTen_ES
dc.titleReceptors involved in dexketoprofen analgesia in murine visceral painen_ES
dc.typeArticuloen_ES
uv.catalogadorRCR DIBRAen_ES
uv.departamentoInstituto de Fisiologiaen_ES

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