Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Aloysia polystachya Harvested in Central Chile

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dc.contributor.authorCatalina Moller, Alejandra
dc.contributor.authorParra, Carol
dc.contributor.authorSaid, Bastian
dc.contributor.authorWerner, Enrique
dc.contributor.authorFlores, Susana
dc.contributor.authorVillena, Joan
dc.contributor.authorRusso, Alessandra
dc.contributor.authorCaro, Nelson
dc.contributor.authorMontenegro, Iván
dc.contributor.authorMadrid, Alejandro
dc.date.accessioned2022-11-30T02:46:37Z
dc.date.available2022-11-30T02:46:37Z
dc.date.issued2021
dc.description.abstractThe aim of this study was to determine, first, the chemical composition of Aloysia polystachya (Griseb) Moldenke essential oil, from leaves harvested in central Chile; and second, its antioxidant and cytotoxic activity. Eight compounds were identified via gas chromatography–mass spectrometry (GC–MS) analyses, with the most representative being R-carvone (91.03%), R-limonene (4.10%), and dihydrocarvone (1.07%). For Aloysia polystachya essential oil, antioxidant assays (2,2-diphenyl1-picrylhydrazyl (DPPH), H2O2, ferric reducing antioxidant power (FRAP), and total reactive antioxidant potential (TRAP)) showed good antioxidant activity compared to commercial antioxidant controls; and anti-proliferative assays against three human cancer cell lines (colon, HT-29; prostate, PC-3; and breast, MCF-7) determined an IC50 of 5.85, 6.74, and 9.53 μg/mL, and selectivity indices of 4.75, 4.12, and 2.92 for HT-29, PC-3, and MCF-7, respectively. We also report on assays with CCD 841 CoN (colon epithelial). Overall, results from this study may represent, in the near future, developments for natural-based cancer treatments.en_ES
dc.facultadFacultad de Medicinaen_ES
dc.file.nameMoller_Anti2021.pdf
dc.identifier.citationMoller, A.C.; Parra, C.; Said,B.; Werner, E.; Flores, S.; Villena, J.;Russo, A.; Caro, N.; Montenegro, I.;Madrid, A.et al. Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Aloysia polystachya Harvested in Central Chile. Molecules 2021, 26, 131. https://doi.org/10.3390/molecules26010131en_ES
dc.identifier.doihttps://doi.org/10.3390/molecules26010131
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7440
dc.languageen
dc.publisherMDPI
dc.rightsCopyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.sourceMolecules
dc.subjectALOYSIA POLYSTACHYAen_ES
dc.subjectTERPENOIDSen_ES
dc.subjectCYTOTOXIC ACTIVITYen_ES
dc.subjectSELECTIVITY INDEXen_ES
dc.titleAntioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Aloysia polystachya Harvested in Central Chile
dc.typeArticulo
uv.departamentoEscuela de Tecnologia Medica

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