The Antinociceptive Activities of Certain NSAIDS Combinations in Murine Orofacial Test

Vista sencilla de ítem
dc.contributor.authorMiranda, Hugo F.
dc.contributor.authorNoriega, Viviana
dc.contributor.authorSierralta, Fernando
dc.contributor.authorSotomayor-Zárate, Ramón
dc.contributor.authorPrieto, Juan Carlos
dc.date.accessioned2022-03-08T20:05:54Z
dc.date.available2022-03-08T20:05:54Z
dc.date.issued2020
dc.description.abstractPain models are mostly in rodents and between them formalin orofacial test allow discrimination among antinociception and anti-inflammation. This assay use a formalin solution injected into the upper right lip of each mouse which produces two periods of pain separated by an inactive period. The aims of the present study were to evaluate, by means of the isobolographic analysis, the antinociception and anti-inflammatory activities of the following NSAIDs: dexketoprofen, diclofenac, piroxicam and metamizole in an orofacial. The NSAIDs administered intraperitoneally produced a dose-dependent activity with the following order of potency of the rubbing behavior, in phase I: diclofenac > dexketoprofen > piroxicam > metamizole and in the phase II: metamizole > diclofenac > piroxicam > dexketoprofen. The coadministration of NSAIDs resulted in a synergistic interaction, which according to the value of the potency of the combination (II) presents the following range: dexketoprofen plus metamizole > dexketoprofen plus diclofenac > dexketoprofen plus piroxicam, in phase I and dexketoprofen plus metamizole > dexketoprofen plus piroxicam > dexketoprofen plus diclofenac, on the phase II. Data obtained in this work corroborate that NSAIDs alone or in combination inducing activities by additional mechanism of action supplementary to inhibition of COXs. This fact represent a novel approach that could be used as multimodal management of orofacial pain, since with this treatment strategies, by the reduction of doses, can help to diminish side effects of other dugs such opioids.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.identifier.doi10.1055/a-1217-6777
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/3795
dc.language.isoenen_ES
dc.publisherThiemeen_ES
dc.rights© Georg Thieme Verlag KG Stuttgart · New Yorken_ES
dc.sourceDrug Researchen_ES
dc.subjectNSAIDSen_ES
dc.subjectSYNERGISMen_ES
dc.subjectNOCICEPTIONen_ES
dc.subjectINFLAMMATIONen_ES
dc.subjectFORMALIN TESTen_ES
dc.titleThe Antinociceptive Activities of Certain NSAIDS Combinations in Murine Orofacial Testen_ES
dc.typeArticuloen_ES
uv.catalogadorRCR DIBRAen_ES
uv.departamentoInstituto de Fisiologiaen_ES

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
2020 Sotomayor-Zárate R. Drug Research (2nd).pdf
Tamaño:
238.65 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
384 B
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos investigadores UV