Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus

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dc.contributor.authorFuenzalida, Marco
dc.contributor.authorChiu, Chiayu Q.
dc.contributor.authorChávez, Andrés E.
dc.date.accessioned2022-11-30T02:46:21Z
dc.date.available2022-11-30T02:46:21Z
dc.date.issued2021
dc.description.abstractLong-term changes in synaptic transmission between neurons in the brain are considered the cellular basis of learning and memory. Over the last few decades, many studies have revealed that the precise order and timing of activity between pre- and post-synaptic cells (“spike-timing-dependent plasticity; STDP”) is crucial for the sign and magnitude of long-term changes at many central synapses. Acetylcholine (ACh) via the recruitment of diverse muscarinic receptors is known to influence STDP in a variety of ways, enabling flexibility and adaptability in brain network activity during complex behaviors. In this review, we will summarize and discuss different mechanistic aspects of muscarinic modulation of timing-dependent plasticity at both excitatory and inhibitory synapses in the hippocampus to shape learning and memory.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameFuenzalida_Mic2021.pdf
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2020.08.015
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7336
dc.languageen
dc.publisherElsevier
dc.rights© 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
dc.sourceNeuroscience
dc.subjectSYNAPTIC PLASTICITYen_ES
dc.subjectSTDPen_ES
dc.subjectACETYLCHOLINEen_ES
dc.subjectMUSCARINIC RECEPTORSen_ES
dc.subjectPYRAMIDAL NEURONSen_ES
dc.subjectINTERNEURONSen_ES
dc.titleMuscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso
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