Chemical Analysis and In Vitro Bioactivity of Essential Oil of Laurelia sempervirens and Safrole Derivatives against Oomycete Fish Pathogens

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dc.contributor.authorMadrid, Alejandro
dc.contributor.authorLizeth Morales, Ana
dc.contributor.authorSaffirio, Valentina
dc.contributor.authorCuellar, Mauricio A.
dc.contributor.authorWerner, Enrique
dc.contributor.authorSaid, Bastián
dc.contributor.authorGodoy, Patricio
dc.contributor.authorCaro, Nelson
dc.contributor.authorMelo, Mirna
dc.contributor.authorMontenegro, Iván
dc.date.accessioned2022-11-30T02:46:30Z
dc.date.available2022-11-30T02:46:30Z
dc.date.issued2021
dc.description.abstractIn this study, the essential oil (EO) from Laurelia sempervirens was analyzed by GC/MS and safrole (1) was identified as the major metabolite 1, was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side chain, and eight compounds (4 to 12) were obtained by the process. EO and compounds 4–12 were subjected to biological assays on 24 strains of the genus Saprolegnia, specifically of the species 12 S. parasitica and 12 S. australis. EO showed a significant effect against Saprolegnia strains. Compound 6 presents the highest activity against two resistant strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 25 to 100 and 75 to 125 μg/mL, respectively. The results show that compound 6 exhibited superior activities compared to the commercial controls bronopol and azoxystrobin used to combat these pathogens.en_ES
dc.facultadFacultad de Farmaciaen_ES
dc.file.nameMadrid_Che2021.pdf
dc.identifier.citationMadrid, A.; Morales, A.L.; Saffirio, V.; Cuellar, M.A.; Werner, E.; Said, B.; Godoy, P.; Caro, N.; Melo, M.; Montenegro, I. Chemical Analysis and In Vitro Bioactivity of Essential Oil of Laurelia sempervirens and Safrole Derivatives against Oomycete Fish Pathogens. Molecules 2021, 26, 6551. https://doi.org/10.3390/molecules26216551en_ES
dc.identifier.doihttps://doi.org/10.3390/molecules26216551
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7397
dc.languageen
dc.publisherMDPI
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.sourceMolecules
dc.subjectLAURELIA SEMPERVIRENSen_ES
dc.subjectSAFROLen_ES
dc.subjectSAPROLEGNIOSISen_ES
dc.subjectNITROCOMPOUNDSen_ES
dc.titleChemical Analysis and In Vitro Bioactivity of Essential Oil of Laurelia sempervirens and Safrole Derivatives against Oomycete Fish Pathogens
dc.typeArticulo
uv.departamentoInstituto de Estadistica

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