Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish

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dc.contributor.authorViscarra, Franco
dc.contributor.authorGonzález-Gutiérrez, Juan
dc.contributor.authorEsparza, Erica
dc.contributor.authorFigueroa, Carla
dc.contributor.authorPaillali, Pablo
dc.contributor.authorHödar-Salazar, Martin
dc.contributor.authorCéspedes, Camilo
dc.contributor.authorQuiroz, Gabriel
dc.contributor.authorSotomayor-Zárate, Ramón
dc.contributor.authorReyes-Parada, Miguel
dc.contributor.authorBermúdez, Isabel
dc.contributor.authorIturriaga-Vásquez, Patricio
dc.date.accessioned2022-03-10T20:09:54Z
dc.date.available2022-03-10T20:09:54Z
dc.date.issued2020
dc.description.abstractZebrafish is becoming a popular animal model in neuropharmacology and drug discovery, mainly due to its ease of handling and low costs involved in maintenance and experimental work. This animal displays a series of complex behaviours that makes it useful for assessing the effects of psychoactive drugs. Here, adult zebrafish were used for assessment of the anxiolytic and anti-addictive properties of UFR2709, a nicotinic receptor (nAChR) antagonist, using two behavioural paradigms to test for addiction, the novel tank diving test to assess anxiety and the conditioned place preference (CPP). Furthermore, the expression of nAChR subunits α4 and α7 was measured in the zebrafish brain. The results show that UFR2709 exhibits an anxiolytic effect on zebrafish and blocks the effect evoked by nicotine on CPP. Moreover, UFR2709 significantly decreased the expression of α4 nicotinic receptor subunit. This indicates that UFR2709 might be a useful drug for the treatment of nicotine addiction.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.identifier.doihttps://doi.org/10.3390/molecules25132998
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/3802
dc.language.isoenen_ES
dc.publisherMDPIen_ES
dc.sourceMoleculesen_ES
dc.subjectCONDITIONED PLACE PREFERENCE (CPP)en_ES
dc.subjectNOVEL TANK TEST (NTT)en_ES
dc.subjectNICOTINIC RECEPTORen_ES
dc.subjectANXIETYen_ES
dc.subjectREWARDen_ES
dc.subjectZEBRAFISHen_ES
dc.titleNicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafishen_ES
dc.typeArticuloen_ES
uv.catalogadorRCR DIBRAen_ES
uv.departamentoInstituto de Fisiologiaen_ES

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