Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells

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dc.contributor.authorHarcha, Paloma A.
dc.contributor.authorLópez-López, Tamara
dc.contributor.authorPalacios, Adrián G.
dc.contributor.authorSáez, Pablo J.
dc.date.accessioned2022-11-30T02:46:25Z
dc.date.available2022-11-30T02:46:25Z
dc.date.issued2021
dc.description.abstractThe role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated autocrine and paracrine signaling. We also summarize the contribution of PANXs with the cytoskeleton, which is also key regulator of cell migration. PANXs, as mechanosensitive ATP releasing channels, provide a unique link between cell migration and purinergic communication. The functional association with several purinergic receptors, together with a plethora of signals that modulate their opening, allows PANX channels to integrate physical and chemical cues during inflammation. Ubiquitously expressed in almost all immune cells, PANX1 opening has been reported in different immunological contexts. Immune activation is the epitome coordination between cell communication and migration, as leukocytes (i.e., T cells, dendritic cells) exchange information while migrating towards the injury site. In the current review, we summarized the contribution of PANX channels during immune cell migration and recruitment; although we also compile the available evidence for non-immune cells (including fibroblasts, keratinocytes, astrocytes, and cancer cells). Finally, we discuss the current evidence of PANX1 and PANX3 channels as a both positive and/or negative regulator in different inflammatory conditions, proposing a general mechanism of these channels contribution during cell migration.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameHarcha_Pan2021.pdf
dc.identifier.citationHarcha PA, Lopez-Lopez T, Palacios AG and Saez PJ (2021) Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells. Front. Immunol. 12:750480. doi: 10.3389/fimmu.2021.750480en_ES
dc.identifier.doihttps://doi.org/10.3389/fimmu.2021.750480
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7365
dc.languageen
dc.publisherFrontiers
dc.sourceFrontiers in Immunology
dc.subjectCELL COMMUNICATIONen_ES
dc.subjectLEUKOCYTESen_ES
dc.subjectCANCERen_ES
dc.subjectINFLAMMATIONen_ES
dc.subjectCA2+ SIGNALINGen_ES
dc.subjectAMOEBOID MIGRATIONen_ES
dc.subjectMESENCHYMAL MIGRATIONen_ES
dc.subjectMECHANOTRANSDUCTIONen_ES
dc.titlePannexin Channel Regulation of Cell Migration: Focus on Immune Cells
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso

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