Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer

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dc.contributor.authorGoñi, Francisca J.
dc.contributor.authorPeña-Oyarzún, Daniel
dc.contributor.authorTorres, Vicente A.
dc.contributor.authorReyes, Montserrat
dc.date.accessioned2022-11-30T02:46:47Z
dc.date.available2022-11-30T02:46:47Z
dc.date.issued2021
dc.description.abstractBackground: Oral cancer represents the sixth most common cancer in the world and is associated with 40-50% survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant lesions, which, according to histopathological criteria, are referred to as oral dysplasia and their diagnosis are associated with higher rates of malignant transformation towards cancer. We recently reported that aberrant activation of the Wnt/β catenin pathway is due to overexpression of Wnt ligands in oral dysplasia. However, the expression of other regulators of this pathway, namely components of the β-catenin destruction complex has not been explored in oral dysplasia. Material and Methods: Using immunohistochemical analyses, we evaluated nuclear expression of β catenin and its association with Wnt3a and Wnt5a. Likewise, components of the β-catenin destruction complex, including Adenomatous Polyposis Coli (APC), Axin and Glycogen Synthase Kinase 3 beta (GSK-3β) were also evaluated in oral dysplasia and OSCC biopsies. Results: We found that moderate and severe dysplasia samples, which harbored increased expression of nuclear β catenin, depicted augmented cytoplasmic expression of GSK 3β, Axin and APC, in comparison with OSCC samples. Also, GSK-3β was found nuclear in mild dysplasia and OSCC samples, when compared with other study samples. Conclusions: Cytoplasmic levels of components of the β-catenin destruction complex are increased in oral dysplasia and might be responsible of augmented nuclear β catenin.en_ES
dc.facultadFacultad de Medicinaen_ES
dc.file.namePeña_Expr2021.pdf
dc.identifier.citationGoñi FJ, Peña‐Oyarzún D, Torres VA, Reyes M. Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer. Med Oral Patol Oral Cir Bucal. 2021 Nov 1;26 (6):e729-37.en_ES
dc.identifier.doi10.4317/medoral.24528
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7490
dc.languageen
dc.publisherMedicina Oral S.L.
dc.sourceMedicina oral, patología oral y cirugía bucal
dc.subjectORAL CANCERen_ES
dc.subjectORAL DYSPLASIAen_ES
dc.subjectΒ-CATENINen_ES
dc.subjectWNT LIGANDSen_ES
dc.subjectDESTRUCTION COMPLEXen_ES
dc.titleExpression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer
dc.typeArticulo
uv.departamentoInterdisciplinary Center for Research in Territorial Health of the Aconcagua Valley (CIISTe Aconcagua)
uv.notageneralNo disponible para descarga

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