Pharmacological Characterization of 4- Methylthioamphetamine Derivatives

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dc.contributor.authorGuajardo, Fabrizzio G.
dc.contributor.authorVelásquez, Victoria B.
dc.contributor.authorRaby, Daniela
dc.contributor.authorNúñez-Vivanco, Gabriel
dc.contributor.authorIturriaga-Vásquez, Patricio
dc.contributor.authorEspaña, Rodrigo A.
dc.contributor.authorMiguel, Reyes-Parada
dc.contributor.authorSotomayor-Zárate, Ramón
dc.date.accessioned2022-03-10T19:01:16Z
dc.date.available2022-03-10T19:01:16Z
dc.date.issued2020
dc.description.abstractAmphetamine derivatives have been used in a wide variety of pathologies because of their pharmacological properties as psychostimulants, entactogens, anorectics, and antidepressants. However, adverse cardiovascular effects (sympathomimetics) and substance abuse problems (psychotropic and hallucinogenic effects) have limited their use. 4-Methylthioamphetamine (MTA) is an amphetamine derivative that has shown to inhibit monoamine uptake and monoamine oxidase. However, the pharmacological characterization (neurochemical, behavioral, and safety) of its derivatives 4-ethylthioamphetamine (ETA) and 4-methylthio-phenil-2-butanamine (MT-But) have not been studied. In the current experiments, we show that ETA and MT-But do not increase locomotor activity and conditioned place preference with respect to MTA. At the neurochemical level, ETA and MT-But do not increase in vivo DA release in striatum, but ETA and MT-But affect the nucleus accumbens bioaccumulation of DA and DOPAC. Regarding cardiovascular effects, the administration of MTA and ETA increased the mean arterial pressure and only ETA significantly increases the heart rate. Our results show that the pharmacological and safety profiles of MTA are modulated by changing the methyl-thio group or the methyl group of the aminoethyl chain.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.identifier.doi10.3390/molecules25225310
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/3801
dc.language.isoenen_ES
dc.publisherMDPIen_ES
dc.sourceMoleculesen_ES
dc.subjectCONDITIONED PLACE PREFERENCE (CPP)en_ES
dc.subjectDATen_ES
dc.subjectLOCOMOTOR ACTIVITYen_ES
dc.subjectREWARDen_ES
dc.subjectFSCVen_ES
dc.subjectMOLECULAR DOCKINGen_ES
dc.titlePharmacological Characterization of 4- Methylthioamphetamine Derivativesen_ES
dc.typeArticuloen_ES
uv.catalogadorRCR DIBRAen_ES
uv.departamentoInstituto de Fisiologiaen_ES

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