Structural Features of the Human Connectome That Facilitate the Switching of Brain Dynamics via Noradrenergic Neuromodulation

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dc.contributor.authorCoronel-Oliveros, Carlos
dc.contributor.authorCastro, Samy
dc.contributor.authorCofré, Rodrigo
dc.contributor.authorOrio, Patricio
dc.date.accessioned2022-11-30T02:46:17Z
dc.date.available2022-11-30T02:46:17Z
dc.date.issued2021
dc.description.abstractThe structural connectivity of human brain allows the coexistence of segregated and integrated states of activity. Neuromodulatory systems facilitate the transition between these functional states and recent computational studies have shown how an interplay between the noradrenergic and cholinergic systems define these transitions. However, there is still much to be known about the interaction between the structural connectivity and the effect of neuromodulation, and to what extent the connectome facilitates dynamic transitions. In this work, we use a whole brain model, based on the Jasen and Rit equations plus a human structural connectivity matrix, to find out which structural features of the human connectome network define the optimal neuromodulatory effects. We simulated the effect of the noradrenergic system as changes in filter gain, and studied its effects related to the global-, local-, and meso-scale features of the connectome. At the global-scale, we found that the ability of the network of transiting through a variety of dynamical states is disrupted by randomization of the connection weights. By simulating neuromodulation of partial subsets of nodes, we found that transitions between integrated and segregated states are more easily achieved when targeting nodes with greater connection strengths—local feature—or belonging to the rich club—meso-scale feature. Overall, our findings clarify how the network spatial features, at different levels, interact with neuromodulation to facilitate the switching between segregated and integrated brain states and to sustain a richer brain dynamics.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameCoronel_Str2021.pdf
dc.identifier.citationCoronel-Oliveros C, Castro S, Cofré R and Orio P (2021) Structural Features of the Human Connectome That Facilitate the Switching of Brain Dynamics via Noradrenergic Neuromodulation. Front. Comput. Neurosci. 15:687075. doi: 10.3389/fncom.2021.687075en_ES
dc.identifier.doihttps://doi.org/10.3389/fncom.2021.687075
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7299
dc.languageen
dc.publisherFrontiers
dc.sourceFrontiers in Computational Neuroscience
dc.subjectWHOLE BRAIN MODELen_ES
dc.subjectNEUROMODULATIONen_ES
dc.subjectINTEGRATION AND SEGREGATIONen_ES
dc.subjectNETWORK TOPOLOGY, NORADRENALINEen_ES
dc.subjectRICH CLUB ORGANIZATIONen_ES
dc.titleStructural Features of the Human Connectome That Facilitate the Switching of Brain Dynamics via Noradrenergic Neuromodulation
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso

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