An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy

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dc.contributor.authorGonzález-Casanova, Jorge
dc.contributor.authorSchmachtenberg, Oliver
dc.contributor.authorMartínez, Agustín D.
dc.contributor.authorSanchez, Helmuth A.
dc.contributor.authorHarcha, Paloma A.
dc.contributor.authorRojas-Gomez, Diana
dc.date.accessioned2022-11-30T02:46:23Z
dc.date.available2022-11-30T02:46:23Z
dc.date.issued2021
dc.description.abstractDiabetic retinopathy (DR) is one of the main causes of vision loss in the working age population. It is characterized by a progressive deterioration of the retinal microvasculature, caused by long-term metabolic alterations inherent to diabetes, leading to a progressive loss of retinal integrity and function. The mammalian retina presents an orderly layered structure that executes initial but complex visual processing and analysis. Gap junction channels (GJC) forming electrical synapses are present in each retinal layer and contribute to the communication between different cell types. In addition, connexin hemichannels (HCs) have emerged as relevant players that influence diverse physiological and pathological processes in the retina. This article highlights the impact of diabetic conditions on GJC and HCs physiology and their involvement in DR pathogenesis. Microvascular damage and concomitant loss of endothelial cells and pericytes are related to alterations in gap junction intercellular communication (GJIC) and decreased connexin 43 (Cx43) expression. On the other hand, it has been shown that the expression and activity of HCs are upregulated in DR, becoming a key element in the establishment of proinflammatory conditions that emerge during hyperglycemia. Hence, novel connexin HCs blockers or drugs to enhance GJIC are promising tools for the development of pharmacological interventions for diabetic retinopathy, and initial in vitro and in vivo studies have shown favorable results in this regard.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameGonzalez_Upd2021.pdf
dc.identifier.citationGonzález-Casanova, J.; Schmachtenberg, O.; Martínez, A.D.; Sanchez, H.A.; Harcha, P.A.; Rojas-Gomez, D. An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy. Int. J. Mol. Sci. 2021, 22, 3194. https://doi.org/10.3390/ijms22063194en_ES
dc.identifier.doihttps://doi.org/10.3390/ijms22063194
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7353
dc.languageen
dc.publisherMDPI
dc.sourceInternational Journal of Molecular Sciences
dc.subjectDIABETIC RETINOPATHYen_ES
dc.subjectCONNEXINen_ES
dc.subjectGAP JUNCTION CHANNELSen_ES
dc.subjectHEMICHANNELSen_ES
dc.titleAn Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso

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