Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines

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dc.contributor.authorWeinstein, Caroline
dc.date.accessioned2021-11-22T19:41:53Z
dc.date.available2021-11-22T19:41:53Z
dc.date.issued2020
dc.description.abstractGlobe artichoke (Cynara scolymus L.) is considered one of the most significant sources of phenolic antioxidants in nature. However, more than 60% of its total volume is discarded for consumption purposes, making available an abundant, inexpensive and profitable source of natural antioxidants in the discarded fractions. Polyphenolic antioxidants from a South American variety of artichoke agro-industrial discards (external bracts and stems) were obtained by mild extraction processes. Best results were achieved at 40 °C, 75% of ethanol and 10 min of reaction, obtaining 2.16 g gallic acid equivalent (GAE)/100 g of total phenolic compounds (TPC) and 55,472.34 µmol Trolox equivalent (TE)/100 g of antioxidant capacity (oxygen radical absorbance capacity (ORAC)). High-performance liquid chromatography (HPLC) analyses determined that caffeoylquinic acids comprise up to 85% of the total polyphenolic content, and only around 5% are flavonoids. Inulin content in the artichokes residues was recovered (48.4% dry weight (dw)), resulting in an extract with 28% of inulin in addition to the aforementioned antioxidant capacity. The artichoke discard extract in a concentration of 500 mg/L produced a strong decrease in Caco-2 and MCF-7 cancer cell lines viability, whereas healthy fibroblasts maintained their viability when the extract was concentrated at 1500 mg/L. These results suggest that the artichoke extract presents a good anti-proliferative potential effect on Caco-2 and MCF-7 cells.en_ES
dc.facultadFacultad de Farmaciaen_ES
dc.identifier.citationNoriega-Rodríguez D, Soto-Maldonado C, Torres-Alarcón C, Pastrana-Castro L, Weinstein-Oppenheimer C, Zúñiga-Hansen ME. Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines. Processes. 2020; 8(6):715. https://doi.org/10.3390/pr8060715en_ES
dc.identifier.doihttps://doi.org/10.3390/pr8060715
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/2716
dc.language.isoenen_ES
dc.publisherMDPIen_ES
dc.sourceProcessesen_ES
dc.subjectARTICHOKE DISCARDSen_ES
dc.subjectPOLYPHENOLSen_ES
dc.subjectANTIOXIDANT ACTIVITYen_ES
dc.subjectINULINen_ES
dc.subjectCACO-2en_ES
dc.subjectMCF-7en_ES
dc.titleValorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Linesen_ES
dc.typeArticuloen_ES
uv.catalogadorRCR DIBRAen_ES
uv.departamentoEscuela de Quimica y Farmaciaen_ES
uv.notageneralVarios autoresen_ES

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