Plasticity in Colorectal Cancer: Why Cancer Cells Differentiate

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dc.contributor.authorWalter, Romina Judith
dc.contributor.authorSonnentag, Steffen Joachim
dc.contributor.authorOrian-Rousseau, Véronique
dc.contributor.authorMunoz-Sagredo, Leonel
dc.date.accessioned2022-11-30T02:47:10Z
dc.date.available2022-11-30T02:47:10Z
dc.date.issued2021
dc.description.abstractThe cancer stem cell hypothesis poses that the bulk of differentiated cells are non-tumorigenic and only a subset of cells with self-renewal capabilities drive tumor initiation and progression. This means that differentiation could have a tumor-suppressive effect. Accumulating evidence shows, however, that in some solid tumors, like colorectal cancer, such a hierarchical organization is necessary. The identification of Lgr5 as a reliable marker of normal intestinal epithelial stem cells, together with strategies to trace cell lineages within tumors and the possibility to selectively ablate these cells, have proven the relevance of Lgr5+ cells for cancer progression. On the contrary, the role of Lgr5− cells during this process remains largely unknown. In this review, we explore available evidence pointing towards possible selective advantages of cancer cells organized hierarchically and its resulting cell heterogeneity. Clear evidence of plasticity between cell states, in which loss of Lgr5+ cells can be replenished by dedifferentiation of Lgr5− cells, shows that cell hierarchies could grant adaptive traits to tumors upon changing selective pressures, including those derived from anticancer therapy, as well as during tumor progression to metastasis.en_ES
dc.facultadFacultad de Medicinaen_ES
dc.file.nameWalter_Pla2021.pdf
dc.identifier.citationWalter, R.J.; Sonnentag, S.J.; Orian-Rousseau, V.; Munoz-Sagredo, L. Plasticity in Colorectal Cancer: Why Cancer Cells Differentiate. Cancers 2021, 13, 918. https://doi.org/10.3390/cancers13040918en_ES
dc.identifier.doihttps://doi.org/10.3390/cancers13040918
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7588
dc.languageen
dc.publisherMDPI
dc.rightsCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.sourceCancers
dc.subjectCOLORECTAL CANCERen_ES
dc.subjectCANCER STEM CELLSen_ES
dc.subjectPLASTICITYen_ES
dc.subjectCANCER STEM CELL MARKERSen_ES
dc.subjectTUMOR HETEROGENEITYen_ES
dc.subjectTUMOR-ORGANOIDSen_ES
dc.subjectLINEAGE TRACINGen_ES
dc.subjectCLONAL COOPERATIONen_ES
dc.subjectRADIO-RESISTANCEen_ES
dc.subjectSERIAL TRANSPLANTATIONen_ES
dc.subjectTHERAPEUTIC RESISTANCEen_ES
dc.titlePlasticity in Colorectal Cancer: Why Cancer Cells Differentiate
dc.typeArticulo

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