Pre‐ and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption

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dc.contributor.authorPlaza, Wladimir
dc.contributor.authorGaschino, Felice
dc.contributor.authorGutiérrez, Camilo
dc.contributor.authorSantibañez, Nicolás
dc.contributor.authorEstay‐Olmos, Camila
dc.contributor.authorSotomayor‐Zárate, Ramón
dc.contributor.authorDe la Fuente‐Ortega, Erwin
dc.contributor.authorPautass, Ricardo M.
dc.contributor.authorHaeger, Paola A.
dc.date.accessioned2022-03-10T18:48:36Z
dc.date.available2022-03-10T18:48:36Z
dc.date.issued2019
dc.description.abstractRepeated exposure to alcohol increases retrieval of fear‐conditioned memories, which facilitates, among other factors, the emergence of post‐traumatic stress disorder (PTSD). Individuals with PTSD are more likely to develop alcohol and substance abuse related disorders. We assessed if prenatal and early postnatal alcohol exposure (PAE) increased the susceptibility to retain aversive memories and if this was associated with subsequent heightened alcohol consumption. Pregnant Sprague‐Dawley rats were exposed for 22 hr/day, throughout pregnancy and until postnatal Day 7 to a single bottle of sucralose ‐ sweetened 10% alcohol solution (PAE Group), or to a single bottle of tap water and sucralose (Control Group). Auditory fear conditioning (AFC) was performed in the adolescent offspring at postnatal Day 40. Freezing was measured during acquisition, retention and extinction phases, followed by 3 weeks of free choice alcohol intake. Female, but not male, PAE rats exhibited impaired extinction of the aversive memory, a finding associated with higher levels of 3‐4 Dihidroxyphenylacetic acid (DOPAC) in the nucleus accumbens and heightened alcohol intake, respect to controls. These findings suggest that PAE makes females more vulnerable to long‐term retention of aversive memories, which coexist with heightened alcohol intake. These findings are reminiscent of those of PTSDen_ES
dc.facultadFacultad de Cienciasen_ES
dc.identifier.doi10.1002/dev.21925
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/3800
dc.language.isoenen_ES
dc.publisherWileyen_ES
dc.rights© 2019 Wiley Periodicals, Inc.en_ES
dc.sourceDevelopmental Psychobiologyen_ES
dc.subjectALCOHOL USE DISORDERen_ES
dc.subjectAUDITORY FEAR MEMORYen_ES
dc.subjectAVERSIVE MEMORYen_ES
dc.subjectFETAL ALCOHOL SYNDROMEen_ES
dc.subjectPOST‐TRAUMATIC STRESS DISORDERSen_ES
dc.titlePre‐ and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumptionen_ES
dc.typeArticuloen_ES
uv.catalogadorRCR DIBRAen_ES
uv.departamentoInstituto de Fisiologiaen_ES

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