Exposome and foetoplacental vascular dysfunction in gestational diabetes mellitus

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dc.contributor.authorValero, Paola
dc.contributor.authorFuentes, Gonzalo
dc.contributor.authorCornejo, Marcelo
dc.contributor.authorVega, Sofía
dc.contributor.authorGrismaldo, Adriana
dc.contributor.authorPardo, Fabian
dc.contributor.authorGarcía-Rivas, Gerardo
dc.contributor.authorHillebrands, Jan-Luuk
dc.contributor.authorFaas, Marijke M.
dc.contributor.authorCasanello, Paola
dc.contributor.authorBeek, Eline M. Van Der
dc.contributor.authorGoor, Harry Van
dc.contributor.authorSobrevia, Luis
dc.date.accessioned2022-11-30T02:46:45Z
dc.date.available2022-11-30T02:46:45Z
dc.date.issued2021
dc.description.abstractA balanced communication between the mother, placenta and foetus is crucial to reach a successful pregnancy. Several windows of exposure to environmental toxins are present during pregnancy. When the women metabolic status is affected by a disease or environmental toxin, the foetus is impacted and may result in altered development and growth. Gestational diabetes mellitus (GDM) is a disease of pregnancy characterised by abnormal glucose metabolism affecting the mother and foetus. This disease of pregnancy associates with postnatal consequences for the child and the mother. The whole endogenous and exogenous environmental factors is defined as the exposome. Endogenous insults conform to the endo-exposome, and disruptors contained in the immediate environment are the ectoexposome. Some components of the endo-exposome, such as Selenium, vitamins D and B12, adenosine, and a high-fat diet, and ecto-exposome, such as the heavy metals Arsenic, Mercury, Lead and Copper, and per- and polyfluoroakyl substances, result in adverse pregnancies, including an elevated risk of GDM or gestational diabesity. The impact of the exposome on the human placenta’s vascular physiology and function in GDM and gestational diabesity is reviewed.en_ES
dc.facultadFacultad de Medicinaen_ES
dc.file.namePardo_Expo2021.pdf
dc.identifier.citationValero P, Fuentes G, Cornejo M, et al. Exposome and foetoplacental vascular dysfunction in gestational diabetes mellitus. Mol Aspects Med. 2022;87:101019. doi:10.1016/j.mam.2021.101019en_ES
dc.identifier.doihttps://doi.org/10.1016/j.mam.2021.101019
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7485
dc.languageen
dc.publisherElsevier
dc.sourceMolecular Aspects of Medicine
dc.subjectEXPOSOMEen_ES
dc.subjectVASCULARen_ES
dc.subjectDIABESITYen_ES
dc.subjectOBESITYen_ES
dc.subjectGESTATIONAL DIABETESen_ES
dc.subjectGESTATIONAL DIABESITYen_ES
dc.titleExposome and foetoplacental vascular dysfunction in gestational diabetes mellitus
dc.typeArticulo
uv.departamentoInterdisciplinary Centre of Territorial Health Research (CIISTe)
uv.notageneralNo disponible para descarga

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