Long-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats

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dc.contributor.authorBravo-Tobar, Iván D.
dc.contributor.authorFernández, Paola
dc.contributor.authorSáez, Juan C.
dc.contributor.authorDagnino-Subiabre, Alexies
dc.date.accessioned2022-11-30T02:46:13Z
dc.date.available2022-11-30T02:46:13Z
dc.date.issued2021
dc.description.abstractResilience to stress is the ability to quickly adapt to adversity. There is evidence that exposure to prolonged stress triggers neuroinflammation what produces individual differences in stress vulnerability. However, the relationship between stress resilience, neuroinflammation, and depressive-like behaviors remains unknown. The aim of this study was to analyze the long-term effects of social defeat stress (SDS) on neuroinflammation in the hippocampus and depressive-like behaviors. Male rats were subjected to the SDS paradigm. Social interaction was analyzed 1 and 2 weeks after ending the SDS to determine which animals were susceptible or resilient to stress. Neuroinflammation markers glial fibrillary acidic protein, ionized calcium-binding adaptor molecule 1, and elevated membrane permeability in astrocytes and microglia, as well as depressive-like behaviors in the sucrose preference test and forced swim test were evaluated in all rats. One week after SDS, resilient rats increased their sucrose preference, and time spent in the floating behavior decreased in the forced swim test compared to susceptible rats. Surprisingly, resilient rats became susceptible to stress, and presented neuroinflammation 2 weeks after SDS. These findings suggest that SDS-induced hippocampal neuroinflammation persists in post-stress stages, regardless of whether rats were initially resilient or not. Our study opens a new approach to understanding the neurobiology of stress resilience.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameBravo_Lon2021.pdf
dc.identifier.doihttps://doi.org/10.1002/jnr.24902
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7252
dc.languageen
dc.publisherWiley
dc.sourceJournal of Neuroscience Research
dc.subjectDEPRESSIONen_ES
dc.subjectHEMICHANNELSen_ES
dc.subjectHIPPOCAMPUSen_ES
dc.subjectNEUROINFLAMMATIONen_ES
dc.subjectRESILIENCEen_ES
dc.subjectRRID:AB_2827276en_ES
dc.subjectRRID:AB_839504en_ES
dc.subjectRRID:RGD_10395233en_ES
dc.subjectRRID:RGD_2308852en_ES
dc.subjectSTRESSen_ES
dc.titleLong-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats
dc.typeArticulo
uv.departamentoInstituto de Fisiologia
uv.notageneralNo disponible para descarga

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