Gliotransmission: A Novel Target for the Development of Antiseizure Drugs

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dc.contributor.authorRiquelme, Julio
dc.contributor.authorWellmann, Mario
dc.contributor.authorSotomayor-Zárate, Ramón
dc.contributor.authorBonansco, Christian
dc.date.accessioned2022-03-10T18:21:14Z
dc.date.available2022-03-10T18:21:14Z
dc.date.issued2020
dc.description.abstractFor more than a century, epilepsy has remained an incapacitating neurological disorder with a high incidence worldwide. Mesial temporal lobe epilepsy (TLE) is a common type of epilepsy without an effective pharmacological treatment. An increase in excitability and hypersynchrony of electrical neuronal activity during development are typically associated with an excitatory/inhibitory imbalance in the neuronal network. Astrocytes release gliotransmitters, which can regulate neuronal excitability and synaptic transmission; therefore, the classical neurocentric vision of the cellular basis of epileptogenesis has begun to change. Growing evidence suggests that the key contribution of astrocyte-toneuron signaling in the mechanisms underlies the initiation, propagation, and recurrence of seizure activity. The aim of this review was to summarize current evidence obtained from experimental models that suggest how alterations in astroglial modulation of synaptic transmission and neuronal activity contribute to the development of this brain disease. In this article, we will summarize the main pharmacological, Ca2+-imaging, and electrophysiological findings in the gliotransmitter-mediated modulation of neuronal activity and their possible regulation as a novel cellular target for the development of pharmacological strategies for treating refractory epilepsies.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.identifier.doihttps://doi.org/10.1177/1073858420901474
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/3798
dc.language.isoenen_ES
dc.publisherSageen_ES
dc.rights© The Author(s) 2020en_ES
dc.sourceThe Neuroscientisten_ES
dc.subjectGLIOTRANSMISSIONen_ES
dc.subjectDRUG-RESISTANT EPILEPSYen_ES
dc.subjectPURINERGIC RECEPTORSen_ES
dc.subjectGLUTAMATERGIC RECEPTORSen_ES
dc.subjectPHARMACOLOGICAL TARGETSen_ES
dc.subjectCHRONIC EPILEPSY MODELSen_ES
dc.subjectATPen_ES
dc.titleGliotransmission: A Novel Target for the Development of Antiseizure Drugsen_ES
dc.typeArticuloen_ES
uv.catalogadorRCR DIBRAen_ES
uv.departamentoInstituto de Fisiologiaen_ES

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