In vivo pulse-echo measurement of apparent broadband attenuation and Q factor in cortical bone: a preliminary study

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dc.contributor.authorMinonzio, Jean-Gabriel
dc.contributor.authorHan, Chao
dc.contributor.authorCassereau, Didier
dc.contributor.authorGrimal, Quentin
dc.date.accessioned2022-11-30T02:46:35Z
dc.date.available2022-11-30T02:46:35Z
dc.date.issued2021
dc.description.abstractQuantitative ultrasound (QUS) methods have been introduced to assess cortical bone health at the radius and tibia through the assessment of cortical thickness (Ct.Th), cortical porosity and bulk wave velocities. Ultrasonic attenuation is another QUS parameter which is not currently used. We assessed the feasibility of in vivo measurement of ultrasonic attenuation in cortical bone with a broadband transducer with 3.5 MHz center frequency. Echoes from the periosteal and endosteal interfaces were fitted with Gaussian pulses using sparse signal processing. Then, the slope of the broadband ultrasonic attenuation (Ct.nBUA) in cortical bone and quality factor ${Q}_{11}^{-1}$ were calculated with a parametric approach based on the center-frequency shift. Five human subjects were measured at the one-third distal radius with pulse-echo ultrasound, and reference data was obtained with high-resolution x-ray peripheral computed tomography (Ct.Th and cortical volumetric bone mineral density (Ct.vBMD)). Ct.Th was used in the calculation of Ct.nBUA while ${Q}_{11}^{-1}$ is obtained solely from ultrasound data. The values of Ct.nBUA (6.7 ± 2.2 dB MHz−1 .cm−1) and ${Q}_{11}^{-1}$ (8.6 ± 3.1%) were consistent with the literature data and were correlated to Ct.vBMD (${R}^{2}=0.92$, $p\lt 0.01$, RMSE = 0.56 dB.MHz−1.cm−1, and ${R}^{2}=0.93$, $p\lt 0.01$, RMSE = 0.76%). This preliminary study suggests that the attenuation of an ultrasound signal propagating in cortical bone can be measured in vivo at the one-third distal radius and that it provides an information on bone quality as attenuation values were correlated to Ct.vBMD. It remains to ascertain that Ct.nBUA and ${Q}_{11}^{-1}$ measured here exactly reflect the true (intrinsic) ultrasonic attenuation in cortical bone. Measurement of attenuation may be considered useful for assessing bone health combined with the measurement of Ct.Th, porosity and bulk wave velocities in multimodal cortical bone QUS methods.en_ES
dc.facultadFacultad de Ingenieríaen_ES
dc.file.nameMinonzio_In2021.pdf
dc.identifier.citationJean-Gabriel Minonzio et al 2021 Phys. Med. Biol. 66 155002en_ES
dc.identifier.doi10.1088/1361-6560/ac1022
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7431
dc.languageen
dc.publisherIPEM
dc.sourcePhysics in Medicine & Biology
dc.subjectCORTICAL BONEen_ES
dc.subjectBROADBAND ULTRASONIC ATTENUATIONen_ES
dc.subjectQUANTITATIVE ULTRASOUNDen_ES
dc.subjectIN VIVO MEASUREMENTen_ES
dc.subjectORTHOGONAL MATCHING PURSUITen_ES
dc.subjectQ FACTORen_ES
dc.subjectSPARSE RECONSTRUCTIONen_ES
dc.titleIn vivo pulse-echo measurement of apparent broadband attenuation and Q factor in cortical bone: a preliminary study
dc.typeArticulo
uv.departamentoEscuela de Ingenieria Informatica
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