The Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence

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dc.contributor.authorAnreiter, Ina
dc.contributor.authorAllen, Aaron M.
dc.contributor.authorVasquez, Oscar E.
dc.contributor.authorTo, Lydia
dc.contributor.authorDouglas, Scott J.
dc.contributor.authorAlvarez, Javier V.
dc.contributor.authorEwer, John
dc.contributor.authorSokolowski, Marla B.
dc.date.accessioned2022-11-30T02:46:09Z
dc.date.available2022-11-30T02:46:09Z
dc.date.issued2021
dc.description.abstractThe foraging (for) gene has been extensively studied in many species for its functions in development, physiology, and behavior. It is common for genes that influence behavior and development to be essential genes, and for has been found to be an essential gene in both fruit flies and mammals, with for mutants dying before reaching the adult stage. However, the biological process underlying the lethality associated with this gene is not known. Here, we show that in Drosophila melanogaster, some but not all gene products of for are essential for survival. Specifically, we show that promoter 3 of for, but not promoters 1, 2, and 4 are required for survival past pupal stage. We use full and partial genetic deletions of for, and temperature-restricted knock-down of the gene to further investigate the stage of lethality. While deletion analysis shows that flies lacking for die at the end of pupal development, as pharate adults, temperature-restricted knock-down shows that for is only required at the start of pupal development, for normal adult emergence (AE) and viability. We further show that the inability of these mutants to emerge from their pupal cases is linked to deficiencies in emergence behaviors, caused by a possible energy deficiency, and finally, that the lethality of for mutants seems to be linked to protein isoform P3, transcribed from for promoter 3.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameAnreiter_Dro2021.pdf
dc.identifier.citationIna Anreiter, Aaron M. Allen, Oscar E. Vasquez, Lydia To, Scott J. Douglas, Javier V. Alvarez, John Ewer & Marla B. Sokolowski (2021) The Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence, Journal of Neurogenetics, 35:3, 179-191, DOI: 10.1080/01677063.2021.1914608en_ES
dc.identifier.doihttps://doi.org/10.1080/01677063.2021.1914608
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7215
dc.languageen
dc.publisherTaylor & Francis
dc.sourceJournal of Neurogenetics
dc.subjectCOMPLEMENTATION ANALYSISen_ES
dc.subjectECDYSISen_ES
dc.subjectFAT BODYen_ES
dc.subjectFORen_ES
dc.subjectLETHALITYen_ES
dc.subjectPLEIOTROPYen_ES
dc.titleThe Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso
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