Transcranial Red LED Therapy: A Promising Non-Invasive Treatment to Prevent Age-Related Hippocampal Memory Impairment

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dc.contributor.authorJara, Claudia
dc.contributor.authorBuendía, Débora
dc.contributor.authorArdiles, Alvaro
dc.contributor.authorMuñoz Aravena, Pablo
dc.contributor.authorTapia Rojas, Cheril
dc.date.accessioned2022-12-06T15:19:39Z
dc.date.available2022-12-06T15:19:39Z
dc.date.issued2021
dc.description.abstractThe hippocampus is an integral portion of the limbic system and executes a critical role in spatial and recognition learning, memory encoding, and memory consolidation. Hippocampal aging showed neurobiological alterations, including increased oxidative stress, altered intracellular signaling pathways, synaptic impairment, and organelle deterioration such as mitochondrial dysfunction. These alterations lead to hippocampal cognitive decline during aging. Therefore, the search for new non-invasive therapies focused on preserving or attenuating age-related hippocampal memory impairment could have of great impact on aging, considering the increasing life expectancy in the world. Red light Transcranial LED therapy (RL-TCLT) is a promising but little explored strategy, which involves red light LED irradiation without surgical procedures, safe and at a low cost. Nevertheless, the precise mechanism involved and its real impact on age-related cognitive impairment is unclear, due to differences in protocol, wavelength applied, and time. Therefore, in this chapter, we will discuss the evidence about RL-TCLT and its effects on the hippocampal structure and function, and how this therapy could be used as a promising treatment for memory loss during aging and in age-related diseases such as Alzheimer’s Disease (AD). Finally, we will mention our advances in Red 630-light-Transcranial LED therapy on the hippocampus in aging and ADen_ES
dc.facultadFacultad de Ingenieríaen_ES
dc.identifier.doi10.5772/intechopen.100620
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7850
dc.language.isoenen_ES
dc.publisherIntechopenen_ES
dc.rightsThis chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_ES
dc.sourceHippocampus - Cytoarchitecture and Diseasesen_ES
dc.subjectAGINGen_ES
dc.subjectHIPPOCAMPUSen_ES
dc.subjectMEMORYen_ES
dc.subjectLED THERAPYen_ES
dc.subjectMITOCHONDRIAen_ES
dc.titleTranscranial Red LED Therapy: A Promising Non-Invasive Treatment to Prevent Age-Related Hippocampal Memory Impairmenten_ES
dc.typeCapitulo de libroen_ES
uv.catalogadorRCR DIBRAen_ES
uv.departamentoEscuela de Ingenieria Civil Biomedicaen_ES

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