Biological knowledge-slanted random forest approach for the classification of calcified aortic valve stenosis

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Cantor_Bio2021.pdf (1.06 MB)

Fecha

2021

Autores

Profesor GuĆ­a

Formato del documento

Articulo

ORCID Autor

TĆ­tulo de la revista

ISSN de la revista

TĆ­tulo del volumen

Editor

Bmc

UbicaciĆ³n

ISBN

ISSN

item.page.issne

item.page.doiurl

https://doi.org/10.1186/s13040-021-00269-4

URI

http://repositoriobibliotecas.uv.cl/handle/uvscl/7262

Facultad

Facultad de Ciencias

Departamento o Escuela

Instituto de Estadistica

Determinador

Recolector

Especie

Nota general

Resumen

Background. Calcific aortic valve stenosis (CAVS) is a fatal disease and there is no pharmacological treatment to prevent the progression of CAVS. This study aims to identify genes potentially implicated with CAVS in patients with congenital bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) in comparison with patients having normal valves, using a knowledge-slanted random forest (RF). Results. This study implemented a knowledge-slanted random forest (RF) using information extracted from a protein-protein interactions network to rank genes in order to modify their selection probability to draw the candidate split-variables. A total of 15,191 genes were assessed in 19 valves with CAVS (BAV, nā€‰=ā€‰10; TAV, nā€‰=ā€‰9) and 8 normal valves. The performance of the model was evaluated using accuracy, sensitivity, and specificity to discriminate cases with CAVS. A comparison with conventional RF was also performed. The performance of this proposed approach reported improved accuracy in comparison with conventional RF to classify cases separately with BAV and TAV (Slanted RF: 59.3% versus 40.7%). When patients with BAV and TAV were grouped against patients with normal valves, the addition of prior biological information was not relevant with an accuracy of 92.6%. Conclusion. The knowledge-slanted RF approach reflected prior biological knowledge, leading to better precision in distinguishing between cases with BAV, TAV, and normal valves. The results of this study suggest that the integration of biological knowledge can be useful during difficult classification tasks.

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Palabras clave

MACHINE LEARNING, CALCIFIC AORTIC VALVE DISEASE, RANDOM FOREST, PRIOR-KNOWLEDGE, GENE-SELECTION

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This article is licensed under a Creative Commons Attribution 4.0 International License

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ArtĆ­culos investigadores UV