Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease

Vista sencilla de ítem
dc.contributor.authorArriagada-Diaz, Jorge
dc.contributor.authorPrado-Vega, Lorena
dc.contributor.authorCárdenas, Ana M.
dc.contributor.authorArdiles, Alvaro O.
dc.contributor.authorGonzalez-Jamett, Arlek M.
dc.date.accessioned2022-11-30T02:46:11Z
dc.date.available2022-11-30T02:46:11Z
dc.date.issued2022
dc.description.abstractDynamin superfamily proteins (DSPs) comprise a large group of GTP-ases that orchestrate membrane fusion and fission, and cytoskeleton remodeling in different cell-types. At the central nervous system, they regulate synaptic vesicle recycling and signaling-receptor turnover, allowing the maintenance of synaptic transmission. In the presynapses, these GTP-ases control the recycling of synaptic vesicles influencing the size of the ready-releasable pool and the release of neurotransmitters from nerve terminals, whereas in the postsynapses, they are involved in AMPA-receptor trafficking to and from postsynaptic densities, supporting excitatory synaptic plasticity, and consequently learning and memory formation. In agreement with these relevant roles, an important number of neurological disorders are associated with mutations and/or dysfunction of these GTP-ases. Along the present review we discuss the importance of DSPs at synapses and their implication in different neuropathological contexts.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameArriagada_Dyn2022.pdf
dc.identifier.citationArriagada-Diaz J, Prado-Vega L, Cárdenas AM, Ardiles AO, Gonzalez-Jamett AM. Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease. The Neuroscientist. 2022;28(1):41-58. doi:10.1177/1073858420974313en_ES
dc.identifier.doihttps://doi.org/10.1177/1073858420974313
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7230
dc.languageen
dc.publisherSage
dc.rights© The Author(s) 2020
dc.sourceThe Neuroscientist
dc.subjectENDOCYTIC SYNAPTIC VESICLE RECYCLINGen_ES
dc.subjectNEUROSECRETIONen_ES
dc.subjectAMPAR TRAFFICKINGen_ES
dc.subjectSYNAPTIC PLASTICITYen_ES
dc.subjectEXCITATORY SYNAPSESen_ES
dc.subjectDENDRITIC SPINESen_ES
dc.subjectSYNAPTOPATHIESen_ES
dc.subjectDYNAMIN SUPERFAMILYen_ES
dc.subjectDYNAMIN GTP-ASE ACTIVITYen_ES
dc.titleDynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso
uv.notageneralNo disponible para descarga

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Arriagada_Dyn2022_noaccesible_.pdf
Tamaño:
1.48 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar

Colecciones

Artículos investigadores UV