Artículos investigadores UV

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Taxanes for advanced non-small cell lung cancer (Protocol)
(Cochrane, 2018) Madrid, Eva; Barros Monge, Manuel J; Urrútia, Gerard; Roqué I Figuls, Marta; Pérez Bracchiglione, Javier; Vargas Peirano, Manuel; Loézar Hernández, Cristóbal Nicolás; Bonfill Cosp, Xavier
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of taxanes as part of a combined or single‐agent therapy versus other agents or best supportive care as first‐ or second‐line treatment for advanced non‐small cell lung cancer (NSCLC). A secondary objective is to assess different modes or schemes of administration of taxanes in patients with this disease.
Chaos versus noise as drivers of multistability in neural networks
(Chaos, 2018-10-18) Orio, Patricio; Gatica, Marilyn; Herzog, Rubén; Maidana, Jean Paul; Castro, Samy; Xu, Kesheng
The multistable behavior of neural networks is actively being studied as a landmark of ongoing cerebral activity, reported in both functional Magnetic Resonance Imaging (fMRI) and electro- or magnetoencephalography recordings. This consists of a continuous jumping between different partially synchronized states in the absence of external stimuli. It is thought to be an important mechanism for dealing with sensory novelty and to allow for efficient coding of information in an ever-changing surrounding environment. Many advances have been made to understand how network topology, connection delays, and noise can contribute to building this dynamic. Little or no attention, however, has been paid to the difference between local chaotic and stochastic influences on the switching between different network states. Using a conductance-based neural model that can have chaotic dynamics, we showed that a network can show multistable dynamics in a certain range of global connectivity strength and under deterministic conditions. In the present work, we characterize the multistable dynamics when the networks are, in addition to chaotic, subject to ion channel stochasticity in the form of multiplicative (channel) or additive (current) noise. We calculate the Functional Connectivity Dynamics matrix by comparing the Functional Connectivity (FC) matrices that describe the pair-wise phase synchronization in a moving window fashion and performing clustering of FCs. Moderate noise can enhance the multistable behavior that is evoked by chaos, resulting in more heterogeneous synchronization patterns, while more intense noise abolishes multistability. In networks composed of nonchaotic nodes, some noise can induce multistability in an otherwise synchronized, nonchaotic network. Finally, we found the same results regardless of the multiplicative or additive nature of noise.
Characterization of Retinal Functionality at Different Eccentricities in a Diurnal Rodent
(Frontiers in Cellular Neuroscience, 2018-12-03) Escobar, María José; Reyes, César; Herzog, Rubén; Araya, Joaquín; Otero, Mónica; Ibaceta, Cristóbal; Palacios, Adrián G.
Although the properties of the neurons of the visual system that process central and peripheral regions of the visual field have been widely researched in the visual cortex and the LGN, they have scarcely been documented for the retina. The retina is the first step in integrating optical signals, and despite considerable efforts to functionally characterize the different types of retinal ganglion cells (RGCs), a clear account of the particular functionality of cells with central vs. peripheral fields is still wanting. Here, we use electrophysiological recordings, gathered from retinas of the diurnal rodent Octodon degus, to show that RGCs with peripheral receptive fields (RF) are larger, faster, and have shorter transient responses. This translates into higher sensitivity at high temporal frequencies and a full frequency bandwidth when compared to RGCs with more central RF. We also observed that imbalances between ON and OFF cell populations are preserved with eccentricity. Finally, the high diversity of functional types of RGCs highlights the complexity of the computational strategies implemented in the early stages of visual processing, which could inspire the development of bio-inspired artificial systems.
Pre‐ and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption
(Wiley, 2019) Plaza, Wladimir; Gaschino, Felice; Gutiérrez, Camilo; Santibañez, Nicolás; Estay‐Olmos, Camila; Sotomayor‐Zárate, Ramón; De la Fuente‐Ortega, Erwin; Pautass, Ricardo M.; Haeger, Paola A.
Repeated exposure to alcohol increases retrieval of fear‐conditioned memories, which facilitates, among other factors, the emergence of post‐traumatic stress disorder (PTSD). Individuals with PTSD are more likely to develop alcohol and substance abuse related disorders. We assessed if prenatal and early postnatal alcohol exposure (PAE) increased the susceptibility to retain aversive memories and if this was associated with subsequent heightened alcohol consumption. Pregnant Sprague‐Dawley rats were exposed for 22 hr/day, throughout pregnancy and until postnatal Day 7 to a single bottle of sucralose ‐ sweetened 10% alcohol solution (PAE Group), or to a single bottle of tap water and sucralose (Control Group). Auditory fear conditioning (AFC) was performed in the adolescent offspring at postnatal Day 40. Freezing was measured during acquisition, retention and extinction phases, followed by 3 weeks of free choice alcohol intake. Female, but not male, PAE rats exhibited impaired extinction of the aversive memory, a finding associated with higher levels of 3‐4 Dihidroxyphenylacetic acid (DOPAC) in the nucleus accumbens and heightened alcohol intake, respect to controls. These findings suggest that PAE makes females more vulnerable to long‐term retention of aversive memories, which coexist with heightened alcohol intake. These findings are reminiscent of those of PTSD
Development of Fixed Dose Combination Products Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy
(Springer, 2019) Hens, Bart; Corsetti, Maura; Bermejo, Marival; Löbenberg, Raimar; González, Pablo M.; Mitra, V; Desai, Divyakant; Murthy Chilukuri, Dakshina; Aceituno, Alexis
The gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature poses a great challenge for formulation scientists when developing more complex dosage forms such as those combining two or more drugs. Fixed dose combination (FDC) products are two or more single active ingredients combined in a single dosage form. This formulation strategy represents a novel formulation which is as safe and effective compared to every mono-product separately. A complex drug product, to be dosed through a complex route, requires judicious considerations for formulation development. Additionally, it represents a challenge from a regulatory perspective at the time of demonstrating bioequivalence (BE) for generic versions of such drug products. This report gives the reader a summary of a 2-day short course that took place on the third and fourth of November at the Annual Association of Pharmaceutical Scientists (AAPS) meeting in 2018 at Washington, D.C. This manuscript will offer a comprehensive view of the most influential aspects of the GI physiology on the absorption of drugs and current techniques to help understand the fate of orally ingested drug products in the complex environment represented by the GI tract. Through case studies on FDC product development and regulatory issues, this manuscript will provide a great opportunity for readers to explore avenues for successfully developing FDC products and their generic versions.
Inclusión de salud basada en evidencia en carreras de la salud en Chile y el modelo integrado Metodología de la Investigación Científica-Medicina Basada en Evidencia en la Universidad de Valparaíso
(Elsevier, 2019) Papuzinski, Cristian; Loézar, Cristóbal; Carvajal, Natalia; Vargas, Manuel; Borgeat, Marjorie; Madrid, Eva; Pérez-Bracchiglione, Javier; Arancibia, Marcelo
Introducción: La salud basada en evidencia (SBE) integra el uso de la mejor evidencia, la experiencia clínica y los valores y preferencias del paciente para la toma de decisiones. Su incorporación en las carreras sanitarias de Chile es desconocida. Métodos: Se realizó un estudio de corte transversal para evaluar la incorporación de SBE en los programas de las carreras sanitarias en Chile hasta 2019. Se describe la integración del modelo Metodología de la Investigación Científica (MIC)-Medicina Basada en la Evidencia (MBE) en la Escuela de Medicina de la Universidad de Valparaíso. Resultados: Un total de 49 universidades imparten carreras sanitarias. Un 8,13% incorpora SBE como asignatura explícitamente. Todas incorporan asignaturas que potencialmente incluyen contenidos de SBE. Las carreras de Medicina y Enfermería son las que más incorporan SBE, pero solo una carrera de Medicina incluye SBE como asignatura por más de un semestre. El modelo integrado MIC/MBE (4 semestres), orientado en competencias y centrado en el alumno, involucra el diseno ̃ y ejecución de un protocolo de investigación, así como el análisis crítico de la mejor evidencia, integrado con los valores de los pacientes. Conclusión: La incorporación de SBE como asignatura es muy infrecuente en carreras sanitarias chilenas. Se enfatiza su inclusión transdisciplinaria como asignatura individual desde un modelo que integre la ensenanza ̃ de MIC, sobre todo en universidades estatales.
A Comparison of the Maximum Entropy Principle Across Biological Spatial Scales
(Entropy, 2019-10-15) Cofré, Rodrigo; Herzog, Rubén; Corcoran, Derek; Rosas, Fernando E.
Despite their differences, biological systems at different spatial scales tend to exhibit common organizational patterns. Unfortunately, these commonalities are often hard to grasp due to the highly specialized nature of modern science and the parcelled terminology employed by various scientific sub-disciplines. To explore these common organizational features, this paper provides a comparative study of diverse applications of the maximum entropy principle, which has found many uses at different biological spatial scales ranging from amino acids up to societies. By presenting these studies under a common approach and language, this paper aims to establish a unified view over these seemingly highly heterogeneous scenarios.
Efecto del conflicto decisional sobre el control del asma en escolares de 10 a 14 años
(Sociedad Chilena de Enfermedades Respiratorias, 2020) Ciudad A., Daniel; Bravo S., Gabriela; Contreras A., Linrayén; Huenul V., Yocelin
Introducción: La cantidad de pacientes asmáticos que asisten al sistema público de salud es cada vez mayor, no obstante, la tasa de adherencia al tratamiento es muy baja, siendo los adolescentes quienes presentan mayor porcentaje de abandono al tratamiento, inasistencia a sus controles y gran conflicto decisional (CD). El objetivo de este estudio fue evaluar el efecto de la aplicación de consejerías sobre el CD en relación al tratamiento del asma y el nivel de control de su enfermedad. Materiales y Métodos: Estudio pre-experimental que reclutó a 32 niños asmáticos entre 10 a 14 años de edad del policlínico respiratorio infantil del hospital Carlos Van Buren de Valparaíso. Solo 15 niños estuvieron dispuestos a participar en el estudio quienes completaron la totalidad de las sesiones de consejería. Para determinar el grado de CD de su patología, se aplicó la Escala de Conflicto Decisional de Ottawa; y para el nivel del control del asma, se usó la Escala Global Initiative for Asthma (GINA). Resultados: La edad media del grupo de niños fue de 12,06 ± 1,16 años. Finalizada la intervención, el nivel de control de asma se mantuvo y la media del CD disminuyó de 34,05 ± 4,59 a 18,02 ± 3,01 puntos (p < 0,05; t de Student para muestras pareadas). Un 73,3% de los pacientes disminuyó su nivel de conflicto decisional. Conclusión: Las consejerías de apoyo decisional demostraron tener efectos positivos en la población estudiada.
Gliotransmission: A Novel Target for the Development of Antiseizure Drugs
(Sage, 2020) Riquelme, Julio; Wellmann, Mario; Sotomayor-Zárate, Ramón; Bonansco, Christian
For more than a century, epilepsy has remained an incapacitating neurological disorder with a high incidence worldwide. Mesial temporal lobe epilepsy (TLE) is a common type of epilepsy without an effective pharmacological treatment. An increase in excitability and hypersynchrony of electrical neuronal activity during development are typically associated with an excitatory/inhibitory imbalance in the neuronal network. Astrocytes release gliotransmitters, which can regulate neuronal excitability and synaptic transmission; therefore, the classical neurocentric vision of the cellular basis of epileptogenesis has begun to change. Growing evidence suggests that the key contribution of astrocyte-toneuron signaling in the mechanisms underlies the initiation, propagation, and recurrence of seizure activity. The aim of this review was to summarize current evidence obtained from experimental models that suggest how alterations in astroglial modulation of synaptic transmission and neuronal activity contribute to the development of this brain disease. In this article, we will summarize the main pharmacological, Ca2+-imaging, and electrophysiological findings in the gliotransmitter-mediated modulation of neuronal activity and their possible regulation as a novel cellular target for the development of pharmacological strategies for treating refractory epilepsies.
The ALPINE-ALMA [CII] survey: Little to no evolution in the [CII]–SFR relation over the last 13 Gyr
(European Southern Observatory, 2020) Ibar, Eduardo; Mendez Hernandez, Hugo
The [C ii] 158 m line is one of the strongest IR emission lines, which has been shown to trace the star formation rate (SFR) of galaxies in the nearby Universe, and up to z 2. Whether this is also the case at higher redshift and in the early Universe remains debated. The ALPINE survey, which targeted 118 star-forming galaxies at 4:4 < z < 5:9, provides a new opportunity to examine this question with the first statistical dataset. Using the ALPINE data and earlier measurements from the literature, we examine the relation between the [C ii] luminosity and the SFR over the entire redshift range from z 4 �� 8. ALPINE galaxies, which are both detected in [C ii] and in dust continuum, show good agreement with the local L([CII])–SFR relation. Galaxies undetected in the continuum by ALMA are found to be over-luminous in [C ii]when the UV SFR is used. After accounting for dust-obscured star formation, by an amount of SFR(IR) SFR(UV) on average, which results from two di erent stacking methods and SED fitting, the ALPINE galaxies show an L([CII])–SFR relation comparable to the local one. When [C ii] non-detections are taken into account, the slope may be marginally steeper at high-z, although this is still somewhat uncertain. When compared homogeneously, the z > 6 [C ii] measurements (detections and upper limits) do not behave very di erently to the z 4 �� 6 data.We find a weak dependence of L([CII])/SFR on the Ly equivalent width. Finally, we find that the ratio L([CII])/LIR (1 �� 3) 10��3 for the ALPINE sources, comparable to that of ‘normal’ galaxies at lower redshift. Our analysis, which includes the largest sample ( 150 galaxies) of [C ii] measurements at z > 4 available so far, suggests no or little evolution of the [C ii]–SFR relation over the last 13 Gyr of cosmic time.
Phytostimulant properties of highly stable silver nanoparticles obtained with saponin extract from Chenopodium quinoa
(Society of Chemical Industry, 2020) Segura, Rodrigo; Vásquez, Gustavo; Colson, Emmanuel; Gerbaux, Pascal; Frischmon, Caroline; Nesic, Aleksandra; García, Danni E; Cabrera-Barjas, Gustavo
BACKGROUND: Quinoa (Chenopodium quinoa Willd) is an Andean original pseudocereal with high nutritional value. During quinoa processing, large amounts of saponin-rich husks byproducts are obtained. Quinoa saponins, which are biologically active, could be used for various agriculture purposes. Silver nanoparticles have increasingly attracted attention for the management of crop diseases in agriculture. In this work, silver nanoparticles are synthesized by a sustainable and green method, using quinoa husk saponin extract (QE) to evaluate their potential for application in agriculture as biostimulants. RESULTS: Quinoa extract was obtained and characterized by liquid chromatography with tandem mass spectrometry (LC–MS/ MS). Sixteen saponin congeners were successfully identified and quantified. The QE obtained was used as a reducing agent for silver ions to synthesize silver nanoparticles (QEAgNPs) under mild conditions. The morphology, particle size, and stability of Ag nanoparticles were investigated by transmission electron microscopy (TEM), ultraviolet–visible spectroscopy (UV-visible), energy-dispersive X-ray (EDS), zeta potential, and Fourier transform infrared spectroscopy with attenuated total reflection (FTIR-ATR). Ultraviolet–visible spectroscopy measurements confirmed the formation of silver nanoparticles in the presence of QE, with estimated particle sizes in a range between 5 and 50 nm. According to the zeta potential values, highly stable nanoparticles were formed. The QE and QEAgNPs (200–1000 ∼g/mL) were also tested in radish seed bioassay to evaluate their phytotoxicity. The seed germination assays revealed that QEAgNPs possessed a phytostimulant effect on radish seeds in a dosedependent manner, and no phytotoxicity was observed for both QE and QEAgNPs. CONCLUSION: Silver nanoparticles obtained by a so-called ‘green’ method could be considered as good candidates for application in the agricultural sector for seed treatment, or as foliar sprays and plant-growth-promoters.
A Story of Four Eggs in Goto Island, Japan
(Coastal Education and Research Foundation, 2020) Winckler Grez, Patricio
Expectancy-Value Model Related to Physical Activity Behaviors in Chilean and Spanish Adolescents
(MDPI, 2020) Gallardo, Laura O.; Abarca-Sos, Alberto; Moreno Doña, Alberto
The purpose of the study is to comparatively test the expectancy-value model in Chilean and Spanish samples. The model proposes: a social world (composed of social support, physical activity teasing, and weight teasing), expectancy (composed of perceived competence and appearance), task values (composed of enjoyment and stress) to predict physical activity and intention to be physically active. Participants were 497 (Chilean) and 1365 (Spanish) adolescents. Structural equation models and multi-group modelling were used. All the models presented adequate fit to the data. The results show that physical activity teasing is a contextual and essential variable; perceived competence and enjoyment influenced physical activity and intentions to be physically active; some differences appeared in the prediction of physical activity and intentions to be physically active when the multi-group model was run. Culturally tailored interventions are key to improving physical activity (PA) behaviors.
The challenge of measuring the phase function of debris disks: Application to HR4796
(European Southern Observatory, 2020) Olofsson, Johan; Bayo, Amelia
Context. Debris discs are valuable systems to study dust properties. Because they are optically thin at all wavelengths, we have direct access to the absorption and scattering properties of the dust grains. One very promising technique to study them is to measure their phase function, that is, the scattering efficiency as a function of the scattering angle. Discs that are highly inclined are promising targets as a wider range of scattering angles can be probed. Aims. The phase function (polarised or total intensity) is usually either inferred by comparing the observations to synthetic disc models, assuming a parametrised phase function or estimating it from the surface brightness of the disc. Here, we argue that the latter approach can be biased due to projection effects leading to an increase in column density along the major axis of a non-flat disc. Methods. We present a novel approach to account for those column density effects. The method remains model dependent, as a disc model is still required to estimate the density variations as a function of the scattering angle. This method allows us, however, to estimate the shape of the phase function without having to invoke any parametrised form. Results. We apply our method to SPHERE/ZIMPOL observations of HR 4796 A and highlight the differences with previous measurements only using the surface brightness; the main differences being at scattering angles smaller than ~100°. Our modelling results suggest that the disc is not vertically flat at optical wavelengths; this result is supported by comparing the width along the major and minor axis of synthetic images. We discuss some of the caveats of the approach, mostly that our method remains blind to real local increases in the dust density and that it cannot be readily applied to angular differential imaging observations yet. Conclusions. We show that the vertical thickness of inclined (≥60°) debris discs can affect the determination of their phase functions. Similarly to previous studies on HR 4796 A, we still cannot reconcile the full picture using a given scattering theory to explain the shape of the phase function, the blow-out size due to radiation pressure, and the shape of the spectral energy distribution, which is a long-lasting problem for debris discs. Nonetheless, we argue that similar effects, such as the ones highlighted in this study, can also bias the determination of the phase function in total intensity.
A mechanistic model of the neural entropy increase elicited by psychedelic drugs
(Nature.com, 2020) Herzog, Rubén; Cofré, Rodrigo
Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity
Assessment of Native and Endemic Chilean Plants for Removal of Cu, Mo and Pb from Mine Tailings
(MDPI, 2020) Lazo, Pamela; Lazo, Andrea
In Chile, 85% of tailings impoundments are inactive or abandoned and many of them do not have a program of treatment or afforestation. The phytoremediation of tailings with Oxalis gigantea, Cistanthe grandiflora, Puya berteroniana and Solidago chilensis have been tested in order to find plants with ornamental value and low water requirements, which enable reductions in molybdenum (Mo), copper (Cu) or lead (Pb) concentrations creating an environmentally friendly surrounding. Ex-situ phytoremediation experiments were carried out for seven months and Mo, Cu and Pb were measured at the beginning and at the end of the growth period. The capacity of these species to phyto-remedy was evaluated using the bioconcentration and translocation factors, along with assessing removal efficiency. Solidago chilensis showed the ability to phytoextract Mo while Puya berteroniana showed potential for Cu and Mo stabilization. The highest removal efficiencies were obtained for Mo, followed by Cu and Pb. The maximum values of removal efficiency for Mo, Cu and Pb were 28.7% with Solidago chilensis, 15.6% with Puya berteroniana and 8.8% with Cistanthe grandiflora, respectively. Therefore, the most noticeable results were obtained with Solidago chilensis for phytoextraction of Mo.
Editorial: Celebrating 40 Years of the Chilean Society of Pharmacology
(Frontiers, 2020) Yévenes, Gonzalo E.; Bravo, Javier A.; Díaz-Araya, Guillermo; Sotomayor-Zárate, Ramón; Fiedler, Jenny L.; Reyes-Parada, Miguel; Fuentealba, Jorge
Editorial on the Research Topic. Celebrating 40 Years of the Chilean Society of Pharmacology
Evidence of climate-driven changes on atmospheric, hydrological, and oceanographic variables along the Chilean coastal zone
(Springer, 2020) Winckler Grez, Patricio; Aguirre, Catalina; Farías, Laura; Contreras-López, Manuel; Masotti, Ítalo
The Chilean coastal zone (CCZ) is subjected to a complex spectrum of anthropogenic, geophysical, biogeochemical, and climate-driven perturbations. Potentially affected variables including atmospheric sea level pressure (Pa), alongshore wind, sea surface temperature (SST), chlorophyll-a, rainfall, river discharge, relative mean sea level (RMSL), and wave climate are studied using in situ and satellite records, hindcasts, and reanalysis datasets. Linear temporal trends and correlations of anomalies are estimated between 18°S and 55°S along the CCZ. The comparison of some of the variables is achieved by means of a strict homogenization procedure on a monthly basis for 35 years. Our findings show that the poleward drift and strengthening of the Southeast Pacific Subtropical Anticyclone (SPSA) partially explains the increase in Pa and reduction in rainfall and river discharge. The enhancement of alongshore winds, also attributable to changes in the SPSA, increases coastal upwelling, which in turn could reduce SST and increase chlorophyll-a. Despite differential latitudinal responses, increasing wave heights and a southward rotation are evidenced. RMSL does not show significant variation as it is presumably affected by seafloor changes during the seismic cycle. Though some correlations are evidenced, the influence of climate variability at decadal scale (PDO, SAM) may be affecting the detected trends due to the short length of available data. Impacts on coastal communities, infrastructure, and ecosystems are discussed, aiming to highlight that coastal vulnerabilities and risk management should be based on the cumulative impacts of these variables.
The ALPINE-ALMA [CII] survey: Small Lya-[CII] velocity offsets in main-sequence galaxies at 4.4 < z < 6
(European Southern Observatory, 2020) Ibar, Eduardo; Mendez Hernandez, Hugo
Context. The Lyman- line in the ultraviolet (UV) and the [CII] line in the far-infrared (FIR) are widely used tools to identify galaxies in the early Universe and to obtain insights into interstellar medium (ISM) properties in high-redshift galaxies. By combining data obtained with ALMA in band 7 at 320 GHz as part of the ALMA Large Program to INvestigate [CII] at Early Times (ALPINE) with spectroscopic data from DEIMOS at the Keck Observatory, VIMOS and FORS2 at the Very Large Telescope, we assembled a unique sample of 53 main-sequence star-forming galaxies at 4:4 < z < 6 in which we detect both the Lyman- line in the UV and the [CII] line in the FIR. Aims. The goal of this paper is to constrain the properties of the Ly emission in these galaxies in relation to other properties of the ISM. Methods. We used [CII], observed with ALMA, as a tracer of the systemic velocity of the galaxies, and we exploited the available optical spectroscopy to obtain the Ly -[CII] and ISM-[CII] velocity offsets. Results. We find that 90% of the selected objects have Ly -[CII] velocity offsets in the range 0 < vLy ��[CII] < 400 km s��1, in line with the few measurements available so far in the early Universe, and significantly smaller than those observed at lower redshifts. At the same time, we observe ISM-[CII] offsets in the range ��500 < vISM��[CII] < 0 km s��1, in line with values at all redshifts, which we interpret as evidence for outflows in these galaxies. We find significant anticorrelations between vLy ��[CII] and the Ly rest-frame equivalent width EW0(Ly ) (or equivalently, the Ly escape fraction fesc(Ly )): galaxies that show smaller vLy ��[CII] have larger EW0(Ly ) and fesc(Ly ). Conclusions. We interpret these results in the framework of available models for the radiative transfer of Ly photons. According to the models, the escape of Ly photons would be favored in galaxies with high outflow velocities, producing large EW0(Ly ) and small vLy ��[CII], in agreement with our observations. The uniform shell model would also predict that the Ly escape in galaxies with slow outflows (0 < vout < 300 km s��1) is mainly determined by the neutral hydrogen column density (NHI) along the line of sight, while the alternative model by Steidel et al. (2010) would more highly favor a combination of NHI at the systemic velocity and covering fraction as driver of the Ly escape. We suggest that the observed increase in Ly escape that is observed in the literature between z 2 and z 6 is not due to a higher incidence of fast outflows at high redshift, but rather to a decrease in average NHI along the line of sight, or alternatively, a decrease in HI covering fraction
Thermodynamic Formalism in Neuronal Dynamics and Spike Train Statistics
(MDPI, 2020) Cofré, Rodrigo
The Thermodynamic Formalism provides a rigorous mathematical framework for studying quantitative and qualitative aspects of dynamical systems. At its core, there is a variational principle that corresponds, in its simplest form, to the Maximum Entropy principle. It is used as a statistical inference procedure to represent, by specific probability measures (Gibbs measures), the collective behaviour of complex systems. This framework has found applications in different domains of science. In particular, it has been fruitful and influential in neurosciences. In this article, we review how the Thermodynamic Formalism can be exploited in the field of theoretical neuroscience, as a conceptual and operational tool, in order to link the dynamics of interacting neurons and the statistics of action potentials from either experimental data or mathematical models. We comment on perspectives and open problems in theoretical neuroscience that could be addressed within this formalism

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