Enhanced innate inmune response in the olfactory sensory system of the zebrafish

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dc.contributor.advisorWhitlock, Kathleen
dc.contributor.authorPalominos Chacón, María
dc.date.accessioned2024-06-11T19:07:53Z
dc.date.available2024-06-11T19:07:53Z
dc.date.issued2021-03
dc.description.abstractThe olfactory system detects odorants in the environment and relays this information to the central nervous system via the olfactory nerve. Over fifty years ago researchers showed that fluids pass from the arachnoid space of the brain across the cribriform plate separating the brain from the peripheral olfactory organs. We now know that fluids drain across the cribriform plate along perineural spaces associated with the olfactory nerves passing through the nasal mucosa to cervical lymph nodes. This olfactory/nasal lymphatic route remains poorly characterized with respect to the potential immune contribution in the protection of the brain from inflammation caused by damage, and viral or bacterial infections. Here we showed that the zebrafish olfactory sensory system has an extensive network of blood- lymphatic vasculature and associated immune cells (neutrophils and macrophages) that forms during early development. This network of lymphatic and blood vasculature is associated with the migration of immune cells towards the olfactory organs in response to copper induced damage and migration of neutrophils is dependent on calcium signaling mediated by L-type Ca2+ channels. In adult animals we showed that the blood-lymphatic vasculature extends across the cribriform plate connecting the peripheral olfactory organs and central nervous system. Two distinct lymphatic cell types were identified in the olfactory organs, one of which accompanies the blood vasculature as it connects the olfactory organs and the central nervous system. Finally, the adult olfactory organs have a large population of resident neutrophils that rapidly increased on number in response to copper-induced damage. The extensive population of resident neutrophils within the olfactory organs suggests that the olfactory organs may act as an immune defense niche for the adult brain. Furthermore, I anticipate that these results will lay the foundations for future research that will shed light on the role of this interface in the life-long neurogenic capacities of the olfactory epithelium, the systemic responses of nasal-delivered drugs, as well as its potential to be used as a point of entry to pathogens (such as the SARS-CoV2 virus, which can access the brain through the olfactory pathway).
dc.facultadFacultad de Ciencias
dc.identifier.urihttps://repositoriobibliotecas.uv.cl/handle/uvscl/13971
dc.language.isoen
dc.publisherUniversidad de Valparaíso
dc.subjectOLFATO
dc.subjectSISTEMA NERVIOSO CENTRAL
dc.subjectMACROFAGOS
dc.subjectNEUTROFILOS
dc.titleEnhanced innate inmune response in the olfactory sensory system of the zebrafish
dc.typeThesis
uv.catalogadorPJR CIEN
uv.colectionTesis
uv.departamentoFacultad de Ciencias. Programa de Doctorado en Ciencias Mención en Neurociencia
uv.notageneralDoctor en Ciencias con mención en Neurociencia. Universidad de Valparaíso. 2021.

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