Efficacy of methadone for the management of postoperative pain in laparoscopic cholecystectomy: A randomized clinical trial

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dc.contributor.authorArriaza, Nicolás
dc.contributor.authorPapuzinski, Cristian
dc.contributor.authorKirmayr, Matías
dc.contributor.authorMatta, Marcelo
dc.contributor.authorAranda, Fenando
dc.contributor.authorStojanova, Jana
dc.contributor.authorMadrid, Eva
dc.date.accessioned2022-11-30T02:46:11Z
dc.date.available2022-11-30T02:46:11Z
dc.date.issued2021
dc.description.abstractBackground: Postoperative pain management contributes to reducing postoperative morbidity and unscheduled readmission. Compared to other opioids that manage postoperative pain like morphine, few randomized trials have tested the efficacy of intraoperatively administered methadone to provide evidence for its regular use or be included in clinical guidelines. Methods: We conducted a randomized clinical trial comparing the use of intraoperative methadone to assess its impact on postoperative pain. Eighty-six patients undergoing elective laparoscopic cholecystectomy were allocated to receive either methadone (0.08 mg/kg) or morphine (0.08 mg/kg). Results: Individuals who received methadone required less rescue morphine in the Post Anesthesia Care Unit for postoperative pain than those who received morphine (p =0.0078). The patients from the methadone group reported less pain at 5 and 15 minutes and 12 and 24 hours following Post Anesthesia Care Unit discharge, exhibiting fewer episodes of nausea. Time to eye-opening was equivalent between the two groups. Conclusion: Intraoperative use of methadone resulted in better management of postoperative pain, supporting its use as part of a multimodal pain management strategy for laparoscopic cholecystectomy under remifentanil-based anesthesia.en_ES
dc.facultadFacultad de Medicinaen_ES
dc.file.nameArriaza_Effic2021.pdf
dc.identifier.citationArriaza N, Papuzinski C, Kirmayr M, Matta M, Aranda F, Stojanova J, et al. Efficacy of methadone for the management of postoperative pain in laparoscopic cholecystectomy: A randomized clinical trial. Medwave 2021;21(2):e8134en_ES
dc.identifier.doi10.5867/medwave.2021.02.8134
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7232
dc.languageen
dc.publisherMedwave
dc.rightsbajo una licencia Creative Commons Atribución-No Comercial 3.0 Unported. Esta licencia permite el uso, distribución y reproducción del artículo en cualquier medio, siempre y cuando se otorgue el crédito correspondiente al autor del artículo y al medio en que se publica, en este caso, Medwave.
dc.sourceMedwave
dc.subjectMETHADONEen_ES
dc.subjectMORPHINEen_ES
dc.subjectPOSTOPERATIVE PAINen_ES
dc.subjectINTRAVENOUS ANESTHESIAen_ES
dc.subjectLAPAROSCOPICen_ES
dc.subjectHOLECYSTECTOMYen_ES
dc.titleEfficacy of methadone for the management of postoperative pain in laparoscopic cholecystectomy: A randomized clinical trial
dc.typeArticulo
uv.departamentoDepartment of Anesthesiology and Reanimation

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