Registered trials address questions already answered with high-certainty evidence: A sample of current redundant research
Date
2021
item.contributor.advisor
item.page.type
Articulo
item.page.orcidurl
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
item.page.ubicacion
item.page.isbn
item.page.issn
item.page.issne
item.page.doiurl
item.page.dc.facultad
Facultad de Medicina
item.page.uv.departamento
Centro Interdisciplinario de Estudios en Salud (CIESAL)
item.page.uv.especie.determinador
item.page.uv.especie.recolector
item.page.uv.especie
item.page.uv.notageneral
No disponible para descarga
Abstract
Objective. To identify clinical trials registered later than 2015, that study the effect of an intervention on a primary outcome whose “Certainty of Evidence” (CoE) has already been rated “high” in a Cochrane SR.
Study Design and Setting. We searched the Cochrane Library for all SRs from 2015. We analyzed SRs of interventions and excluded withdrawn reviews or those with no Summary of Findings (SoF) table. We retrieved the GRADE CoE ratings of each SR's primary outcomes in the SoF tables and identified those rated “high.” We searched the World Health Organization International Clinical Trials Registry Platform and ClinicalTrials to identify records of clinical studies that tackled those outcomes and were registered after the date of publication of the respective 2015 SR.
Results. We selected 602 SRs. Eighty-one contained a “high” CoE rating on at least one primary outcome, totaling 152 primary outcomes rated “high.” We found 39 clinical trials registered for primary outcomes with evidence already rated as “high” in a 2015 Cochrane SR.
Conclusion. This study shows the existence of clinical trials registered to study primary outcomes whose CoE has already been rated “high” in a Cochrane SR.
Description
item.page.coverage.spatial
item.page.sponsorship
Keywords
CLINICAL TRIALS AS TOPIC, SYSTEMATIC REVIEWS AS TOPIC, RESEARCH, GRADE