Registered trials address questions already answered with high-certainty evidence: A sample of current redundant research

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dc.contributor.authorVergara-Merino, Laura
dc.contributor.authorVerdejo, Catalina
dc.contributor.authorAriel Franco, Juan Victor
dc.contributor.authorEscobar Liquitay, Camila
dc.contributor.authorUrrútia, Gerard
dc.contributor.authorKlabundea, Rachel
dc.contributor.authorPérez, Paulina
dc.contributor.authorSánchez, Luna
dc.contributor.authorMadrid, Eva
dc.date.accessioned2022-11-30T02:47:07Z
dc.date.available2022-11-30T02:47:07Z
dc.date.issued2021
dc.description.abstractObjective. To identify clinical trials registered later than 2015, that study the effect of an intervention on a primary outcome whose “Certainty of Evidence” (CoE) has already been rated “high” in a Cochrane SR. Study Design and Setting. We searched the Cochrane Library for all SRs from 2015. We analyzed SRs of interventions and excluded withdrawn reviews or those with no Summary of Findings (SoF) table. We retrieved the GRADE CoE ratings of each SR's primary outcomes in the SoF tables and identified those rated “high.” We searched the World Health Organization International Clinical Trials Registry Platform and ClinicalTrials to identify records of clinical studies that tackled those outcomes and were registered after the date of publication of the respective 2015 SR. Results. We selected 602 SRs. Eighty-one contained a “high” CoE rating on at least one primary outcome, totaling 152 primary outcomes rated “high.” We found 39 clinical trials registered for primary outcomes with evidence already rated as “high” in a 2015 Cochrane SR. Conclusion. This study shows the existence of clinical trials registered to study primary outcomes whose CoE has already been rated “high” in a Cochrane SR.en_ES
dc.facultadFacultad de Medicinaen_ES
dc.file.nameVergara_Reg2021.pdf
dc.identifier.doihttps://doi.org/10.1016/j.jclinepi.2021.01.024
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7576
dc.languageen
dc.publisherElsevier
dc.sourceJournal of Clinical Epidemiology
dc.subjectCLINICAL TRIALS AS TOPICen_ES
dc.subjectSYSTEMATIC REVIEWS AS TOPICen_ES
dc.subjectRESEARCHen_ES
dc.subjectGRADEen_ES
dc.titleRegistered trials address questions already answered with high-certainty evidence: A sample of current redundant research
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Estudios en Salud (CIESAL)
uv.notageneralNo disponible para descarga

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