Anti-parasitic drugs modulate the non-selective channels formed by connexins or pannexins
Archivos
Fecha
2021
Profesor Guía
Formato del documento
Articulo
ORCID Autor
Título de la revista
ISSN de la revista
Título del volumen
Editor
Elsevier
Ubicación
ISBN
ISSN
item.page.issne
item.page.doiurl
Facultad
Facultad de Ciencias
Departamento o Escuela
Centro Interdisciplinario de Neurociencia de Valparaiso
Determinador
Recolector
Especie
Nota general
Resumen
The proteins connexins, innexins, and pannexins are the subunits of non-selective channels present in the cell membrane in vertebrates (connexins and pannexins) and invertebrates (innexins). These channels allow the transfer of ions and molecules across the cell membrane or, and in many cases, between the cytoplasm of neighboring cells. These channels participate in various physiological processes, particularly under pathophysiological conditions, such as bacterial, viral, and parasitic infections. Interestingly, some anti-parasitic drugs also block connexin- or pannexin-formed channels. Their effects on host channels permeable to molecules that favor parasitic infection can further explain the anti-parasitic effects of some of these compounds. In this review, the effects of drugs with known anti-parasitic activity that modulate non-selective channels formed by connexins or pannexins are discussed. Previous studies that have reported the presence of these proteins in worms, ectoparasites, and protozoa that cause parasitic infections have also been reviewed.
Descripción
Lugar de Publicación
Auspiciador
Palabras clave
NEGLECTED TROPICAL DISEASES, CHAGAS DISEASES, SLEEPING SICKNESS, MALARIA, ANTI-PARASITIC DRUGS