Anti-parasitic drugs modulate the non-selective channels formed by connexins or pannexins

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dc.contributor.authorGüiza, Juan
dc.contributor.authorArriagada, Javiera
dc.contributor.authorRodríguez, Luis
dc.contributor.authorGutiérrez, Camila
dc.contributor.authorDuarte, Yorley
dc.contributor.authorSáez, Juan C.
dc.contributor.authorVega, José L.
dc.date.accessioned2022-11-30T02:46:24Z
dc.date.available2022-11-30T02:46:24Z
dc.date.issued2021
dc.description.abstractThe proteins connexins, innexins, and pannexins are the subunits of non-selective channels present in the cell membrane in vertebrates (connexins and pannexins) and invertebrates (innexins). These channels allow the transfer of ions and molecules across the cell membrane or, and in many cases, between the cytoplasm of neighboring cells. These channels participate in various physiological processes, particularly under pathophysiological conditions, such as bacterial, viral, and parasitic infections. Interestingly, some anti-parasitic drugs also block connexin- or pannexin-formed channels. Their effects on host channels permeable to molecules that favor parasitic infection can further explain the anti-parasitic effects of some of these compounds. In this review, the effects of drugs with known anti-parasitic activity that modulate non-selective channels formed by connexins or pannexins are discussed. Previous studies that have reported the presence of these proteins in worms, ectoparasites, and protozoa that cause parasitic infections have also been reviewed.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameGuiza_Ant2021.pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbadis.2021.166188
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7361
dc.languageen
dc.publisherElsevier
dc.sourceBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
dc.subjectNEGLECTED TROPICAL DISEASESen_ES
dc.subjectCHAGAS DISEASESen_ES
dc.subjectSLEEPING SICKNESSen_ES
dc.subjectMALARIAen_ES
dc.subjectANTI-PARASITIC DRUGSen_ES
dc.titleAnti-parasitic drugs modulate the non-selective channels formed by connexins or pannexins
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso

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