Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions

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dc.contributor.authorHarcha, Paloma A.
dc.contributor.authorGarcés, Polett
dc.contributor.authorArredondo, Cristian
dc.contributor.authorFernández, Germán
dc.contributor.authorSáez, Juan C.
dc.contributor.authorVan Zundert, Brigitte
dc.date.accessioned2022-11-30T02:46:25Z
dc.date.available2022-11-30T02:46:25Z
dc.date.issued2021
dc.description.abstractConsidered relevant during allergy responses, numerous observations have also identified mast cells (MCs) as critical effectors during the progression and modulation of several neuroinflammatory conditions, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). MC granules contain a plethora of constituents, including growth factors, cytokines, chemokines, and mitogen factors. The release of these bioactive substances from MCs occurs through distinct pathways that are initiated by the activation of specific plasma membrane receptors/channels. Here, we focus on hemichannels (HCs) formed by connexins (Cxs) and pannexins (Panxs) proteins, and we described their contribution to MC degranulation in AD, ALS, and harmful stress conditions. Cx/Panx HCs are also expressed by astrocytes and are likely involved in the release of critical toxic amounts of soluble factors—such as glutamate, adenosine triphosphate (ATP), complement component 3 derivate C3a, tumor necrosis factor (TNFα), apoliprotein E (ApoE), and certain miRNAs—known to play a role in the pathogenesis of AD, ALS, and other neurodegenerative disorders. We propose that blocking HCs on MCs and glial cells offers a promising novel strategy for ameliorating the progression of neurodegenerative diseases by reducing the release of cytokines and other pro-inflammatory compounds.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.file.nameHarcha_Mas2021.pdf
dc.identifier.citationHarcha, P.A.; Garcés, P.; Arredondo, C.; Fernández, G.; Sáez, J.C.; van Zundert, B. Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions. Int. J. Mol. Sci. 2021, 22, 1924. https://doi.org/10.3390/ijms22041924en_ES
dc.identifier.doihttps://doi.org/10.3390/ijms22041924
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/7364
dc.languageen
dc.publisherMDPI
dc.rightsPublished under an open access Creative Common CC BY license
dc.sourceInternational Journal of Molecular Sciences
dc.subjectHEMICHANNELSen_ES
dc.subjectCONNEXINen_ES
dc.subjectPANNEXINen_ES
dc.subjectMAST CELLSen_ES
dc.subjectGLIAL CELLSen_ES
dc.subjectINFLAMMATIONen_ES
dc.subjectDEGRANULATIONen_ES
dc.subjectNEURODEGENERATIONen_ES
dc.subjectPRO-INFLAMMATORY COMPOUNDSen_ES
dc.subjectGAP JUNCTION CHANNELSen_ES
dc.titleMast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions
dc.typeArticulo
uv.departamentoCentro Interdisciplinario de Neurociencia de Valparaiso

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