GnRH and testosterone treatment generate GnRH neurons in the hypothalamus of adult zebrafish (Danio rerio)

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dc.contributor.advisorWhitlock, Kathleen (Directora de tesis)
dc.contributor.authorCeriani Fernández, Ricardo
dc.date.accessioned2022-08-04T19:56:14Z
dc.date.available2022-08-04T19:56:14Z
dc.date.issued2019-07
dc.description.abstractGonadotropin-releasing hormone (GnRH) is an essential in the control of reproduction of vertebrates. A decrease in the secretion of GnRH causes reproductive disorders called congenital idiopathic hypogonadotropic hypogonadism (IHH), which is characterized by absence of puberty. Once diagnosed, IHH patients can be treated with reproductive hormone therapy to restore the disease. Interestingly, studies have documented a reversion of the disease after discontinuation of hormone treatment, which improves the reproductive capacities. We suggest the hormone treatment stimulate the neurogenesis of GnRH neurons in the hypothalamus in such a way to produce reversion in IHH patients. Here, we characterized the neurogenesis in the preoptic area (POA) of adult zebrafish. Our results showed that GnRH and not testosterone treatment, significantly increased the neurogenesis in the POA. In addition, results obtained by in situ hybridization to gnrh3 and MALDI TOF, did not detect any GnRH isoform in the hypothalamus. Therefore, our results and recent publications show that GnRH does not affect the control of reproduction in zebrafish. In order to find a potential candidate to replace GnRH, we cloned and characterized phoenixin/smim20 expression, which has a reproductive role in mammals. phoenixin/smim20 is widely expressed in the brain especially in the hypothalamus of adult zebrafish.en_ES
dc.facultadFacultad de Cienciasen_ES
dc.identifier.citationCeriani, R. (2019). GnRH and testosterone treatment generate GnRH neurons in the hypothalamus of adult zebrafish (Danio rerio) (Tesis de postgrado). Universidad de Valparaíso, Valparaíso, Chile.en_ES
dc.identifier.urihttp://repositoriobibliotecas.uv.cl/handle/uvscl/4707
dc.language.isoenen_ES
dc.publisherUniversidad de Valparaísoen_ES
dc.subjectNEUROGENESISen_ES
dc.subjectHIPOGONADISMOen_ES
dc.subjectGONADOTROPINAen_ES
dc.subjectBROTES DE ENFERMEDADESen_ES
dc.subjectNEUROGENESISen_ES
dc.titleGnRH and testosterone treatment generate GnRH neurons in the hypothalamus of adult zebrafish (Danio rerio)en_ES
dc.typeTesisen_ES
uv.catalogadorPJR CIENen_ES
uv.departamentoInstituto de Neurocienciaen_ES
uv.notageneralDoctor en Ciencias con Mención en Neurocienciaen_ES

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