Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain models

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2021

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Centro Interdisciplinario de Neurociencia de Valparaiso

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Resumen

Segregation and integration are two fundamental principles of brain structural and functional organization. Neuroimaging studies have shown that the brain transits between different functionally segregated and integrated states, and neuromodulatory systems have been proposed as key to facilitate these transitions. Although whole-brain computational models have reproduced this neuromodulatory effect, the role of local inhibitory circuits and their cholinergic modulation has not been studied. In this article, we consider a Jansen & Rit whole-brain model in a network interconnected using a human connectome, and study the influence of the cholinergic and noradrenergic neuromodulatory systems on the segregation/integration balance. In our model, we introduce a local inhibitory feedback as a plausible biophysical mechanism that enables the integration of whole-brain activity, and that interacts with the other neuromodulatory influences to facilitate the transition between different functional segregation/integration regimes in the brain.

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NEURONA, CHOLINERGICS, NEUROMODULATION, INTERNEURONS, FUNCTIONAL MAGNETIC RESONANCE IMAGING, SIGNAL TO NOISE RATIO, SIGNAL FILTERING, PYRAMIDAL CELLS

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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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