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(Ril editores, 2016) Del Barrio Vásquez, Diego
Taxanes for advanced non-small cell lung cancer (Protocol)
(Cochrane, 2018) Madrid, Eva; Barros Monge, Manuel J; Urrútia, Gerard; Roqué I Figuls, Marta; Pérez Bracchiglione, Javier; Vargas Peirano, Manuel; Loézar Hernández, Cristóbal Nicolás; Bonfill Cosp, Xavier
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of taxanes as part of a combined or single‐agent therapy versus other agents or best supportive care as first‐ or second‐line treatment for advanced non‐small cell lung cancer (NSCLC). A secondary objective is to assess different modes or schemes of administration of taxanes in patients with this disease.
Pre‐ and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption
(Wiley, 2019) Plaza, Wladimir; Gaschino, Felice; Gutiérrez, Camilo; Santibañez, Nicolás; Estay‐Olmos, Camila; Sotomayor‐Zárate, Ramón; De la Fuente‐Ortega, Erwin; Pautass, Ricardo M.; Haeger, Paola A.
Repeated exposure to alcohol increases retrieval of fear‐conditioned memories, which facilitates, among other factors, the emergence of post‐traumatic stress disorder (PTSD). Individuals with PTSD are more likely to develop alcohol and substance abuse related disorders. We assessed if prenatal and early postnatal alcohol exposure (PAE) increased the susceptibility to retain aversive memories and if this was associated with subsequent heightened alcohol consumption. Pregnant Sprague‐Dawley rats were exposed for 22 hr/day, throughout pregnancy and until postnatal Day 7 to a single bottle of sucralose ‐ sweetened 10% alcohol solution (PAE Group), or to a single bottle of tap water and sucralose (Control Group). Auditory fear conditioning (AFC) was performed in the adolescent offspring at postnatal Day 40. Freezing was measured during acquisition, retention and extinction phases, followed by 3 weeks of free choice alcohol intake. Female, but not male, PAE rats exhibited impaired extinction of the aversive memory, a finding associated with higher levels of 3‐4 Dihidroxyphenylacetic acid (DOPAC) in the nucleus accumbens and heightened alcohol intake, respect to controls. These findings suggest that PAE makes females more vulnerable to long‐term retention of aversive memories, which coexist with heightened alcohol intake. These findings are reminiscent of those of PTSD
Development of Fixed Dose Combination Products Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy
(Springer, 2019) Hens, Bart; Corsetti, Maura; Bermejo, Marival; Löbenberg, Raimar; González, Pablo M.; Mitra, V; Desai, Divyakant; Murthy Chilukuri, Dakshina; Aceituno, Alexis
The gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature poses a great challenge for formulation scientists when developing more complex dosage forms such as those combining two or more drugs. Fixed dose combination (FDC) products are two or more single active ingredients combined in a single dosage form. This formulation strategy represents a novel formulation which is as safe and effective compared to every mono-product separately. A complex drug product, to be dosed through a complex route, requires judicious considerations for formulation development. Additionally, it represents a challenge from a regulatory perspective at the time of demonstrating bioequivalence (BE) for generic versions of such drug products. This report gives the reader a summary of a 2-day short course that took place on the third and fourth of November at the Annual Association of Pharmaceutical Scientists (AAPS) meeting in 2018 at Washington, D.C. This manuscript will offer a comprehensive view of the most influential aspects of the GI physiology on the absorption of drugs and current techniques to help understand the fate of orally ingested drug products in the complex environment represented by the GI tract. Through case studies on FDC product development and regulatory issues, this manuscript will provide a great opportunity for readers to explore avenues for successfully developing FDC products and their generic versions.
Inclusión de salud basada en evidencia en carreras de la salud en Chile y el modelo integrado Metodología de la Investigación Científica-Medicina Basada en Evidencia en la Universidad de Valparaíso
(Elsevier, 2019) Papuzinski, Cristian; Loézar, Cristóbal; Carvajal, Natalia; Vargas, Manuel; Borgeat, Marjorie; Madrid, Eva; Pérez-Bracchiglione, Javier; Arancibia, Marcelo
Introducción: La salud basada en evidencia (SBE) integra el uso de la mejor evidencia, la experiencia clínica y los valores y preferencias del paciente para la toma de decisiones. Su incorporación en las carreras sanitarias de Chile es desconocida. Métodos: Se realizó un estudio de corte transversal para evaluar la incorporación de SBE en los programas de las carreras sanitarias en Chile hasta 2019. Se describe la integración del modelo Metodología de la Investigación Científica (MIC)-Medicina Basada en la Evidencia (MBE) en la Escuela de Medicina de la Universidad de Valparaíso. Resultados: Un total de 49 universidades imparten carreras sanitarias. Un 8,13% incorpora SBE como asignatura explícitamente. Todas incorporan asignaturas que potencialmente incluyen contenidos de SBE. Las carreras de Medicina y Enfermería son las que más incorporan SBE, pero solo una carrera de Medicina incluye SBE como asignatura por más de un semestre. El modelo integrado MIC/MBE (4 semestres), orientado en competencias y centrado en el alumno, involucra el diseno ̃ y ejecución de un protocolo de investigación, así como el análisis crítico de la mejor evidencia, integrado con los valores de los pacientes. Conclusión: La incorporación de SBE como asignatura es muy infrecuente en carreras sanitarias chilenas. Se enfatiza su inclusión transdisciplinaria como asignatura individual desde un modelo que integre la ensenanza ̃ de MIC, sobre todo en universidades estatales.
Screening de Lesiones Orales Malignas y Potencialmente Malignas en Funcionarios de Universidad de Valparaíso y Universidad Viña del Mar Durante los Años 2016 - 2017
(Universidad de La Frontera, 2020) Cordero, Karina; Torres, Coral; Anabalón, Paula; Fernández, María José; Suzarte, Josefina; Wu, Kai
El objetivo de este estudio es determinar la prevalencia de lesiones orales malignas y potencialmente malignas (LPM) en funcionarios de la Universidad de Valparaíso y de Viña del Mar durante los años 2016 - 2017. Fueron citados 161 funcionarios, quienes accedieron a una encuesta que evaluaba factores de riesgo de cáncer oral (tabaco y alcohol) y si habían escuchado de la patología, sumado a un examen clínico. De los pacientes examinados, se diagnosticaron 121 lesiones de las cuales 2 fueron diagnosticadas como lesiones potencialmente malignas: Liquen plano y Leucoplasia, con una prevalencia de 1,7 %. El 50,3 % de los pacientes sabía de la existencia de cáncer oral. El Screening es una medida que permite dar a conocer a la población la existencia de cáncer oral y alertarlos sobre la importancia de su examen para su identificación de manera temprana.
Braquiterapia adaptativa guiada por resonancia magnética para el cáncer cervical localmente avanzado: Experiencia del Hospital Carlos Van Buren
(Sociedad Chilena de Obstetricia y Ginecología, 2020) Solis, JA; Olivares, J; Tudela, B; Veillon, G; Perrot, I; Lazcano, G
Introducción y objetivos: El tratamiento estándar para pacientes con cáncer cervical localmente avanzado (CCLA) se basa en radioterapia externa y quimioterapia concomitante seguida de braquiterapia adaptativa guiada por imágenes (BTAGI). El objetivo de este estudio fue describir los resultados del protocolo de BTAGI de resonancia magnética del Servicio de Oncología del Hospital Carlos Van Buren. Métodos: En pacientes con CCLA tratadas con Radioquimioterapia concomitante seguida de BTAGI de resonancia magnética se evaluó la reducción tumoral, parámetros dosimétricos y la toxicidad aguda. Resultados: Se evaluó la reducción tumoral entre el diagnóstico y el momento de la braquiterapia en 34 pacientes. Todas las pacientes completaron el tratamiento de radioterapia externa. Veinticuatro pacientes recibieron 3 sesiones de braquiterapia. Dosis equivalentes totales > 80 Gy se logro en todos los pacientes. Doce pacientes presentaron reducción del volumen tumoral mayor al 70%. La mediana de las dosis equivalentes totales prescritas al D2cc de vejiga fue 73.9 Gy, al recto 65.6 Gy y al intestino fue de 69.1 Gy. Una paciente presento toxicidad gastrointestinal grado ≥ 3. No hubo diferencias estadísticamente significativas al comparar pacientes que recibieron dosis equivalentes totales desde los 85 Gy con las que recibieron menor dosis respecto a toxicidad gastrointestinal (p=0.33) y genitourinaria (p=0.97). Conclusión: La braquiterapia adaptativa guiada por resonancia magnética se puede realizar en el sistema público de salud y cumplir con las recomendaciones internacionales requeridas para el tratamiento estándar del CCLA.
The Gaia-ESO Survey: membership probabilities for stars in 32 open clusters from 3D kinematics
(Royal Astronomical Society, 2020) Bayo, Amelia
The Gaia-ESO Survey (GES) observed many open clusters as part of its programme to spectroscopically characterize the various Milky Way populations. GES spectroscopy and Gaia astrometry from its second data release are used here to assign membership probabilities to targets towards 32 open clusters with ages from 1 to 3800 Myr, based on maximum likelihood modelling of the 3D kinematics of the cluster and field populations. From a parent catalogue of 14 398 individual targets, 5032 stars with uniformly determined 3D velocities, Teff, log g, and chemistry are assigned cluster membership with probability >0.9, and with an average probability of 0.991. The robustness of the membership probabilities is demonstrated using independent membership criteria (lithium and parallax) in two of the youngest clusters. The addition of radial velocities improves membership discrimination over proper motion selection alone, especially in more distant clusters. The kinematically selected nature of the membership lists, independent of photometry and chemistry, makes the catalogue a valuable resource for testing stellar evolutionary models and investigating the time evolution of various parameters.
Stability analysis and constraints on interacting viscous cosmology
(American Physical Society, 2020) Motta, Verónica
In this work we study the evolution of a spatially flat Universe by considering a viscous dark matter and perfect fluids for dark energy and radiation, including an interaction term between dark matter and dark energy. In the first part, we analyse the general properties of the Universe by performing a stability analysis and then we constrain the free parameters of the model using the latest and cosmological-independent measurements of the Hubble parameter. We find consistency between the viscosity coefficient and the condition imposed by the second law of the Thermodynamics. The second part is dedicated to constrain the free parameter of the interacting viscous model (IVM) for three particular cases: the viscous model (VM), interacting model (IM), and the perfect fluid case (the concordance model). We report the deceleration parameter to be q0=−0.54+0.06−0.05, −0.58+0.05−0.04, −0.58+0.05−0.05, −0.63+0.02−0.02, together with the jerk parameter as j0=0.87+0.06−0.09, 0.94+0.04−0.06, 0.91+0.06−0.10, 1.0 for the IVM, VM, IM, and LCDM respectively, where the uncertainties correspond at 68\% CL. Worth mentioning that all the particular cases are in good agreement with LCDM, in some cases producing even better fits, with the advantage of eliminating some problems that afflicts the standard cosmological model.
Cataclysmic variable evolution and the white dwarf mass problem: A Review
(Elsevier, 2020) Zorotovic, Mónica; Schreiber, Matthias R.
Although the theory of cataclysmic variable (CV) evolution is able to explain several observational aspects, strong discrepancies have existed for decades between observations and theoretical predictions of the orbital period distribution, the location of the minimum period, and the space density of CVs. Moreover, it has been shown in the last decade that the average white dwarf (WD) mass observed in CVs is significantly higher than the average mass in single WDs or in detached progenitors of CVs, and that there is an absence of helium-core WDs in CVs which is not observed in their immediate detached progenitors. This highly motivated us to revise the theory of CV formation and evolution. A new empirical model for angular momentum loss in CVs was developed in order to explain the high average WD mass observed and the absence of systems with helium-core WDs. This model seems to help, at the same time, with all of the above mentioned disagreements between theory and observations. Moreover, it also provides us with a very likely explanation for the existence of low-mass WDs without a companion. Here we will review the standard model for CV evolution and the disagreements that have existed for decades between simulations and observations with their possible solutions and/or improvements. We will also summarize the recently confirmed disagreement related to the average WD mass and the fraction of helium-core WDs among CVs, as well as the development of an empirical model that allows us to solve all the disagreements, discussing the physics that could be involved.
An extension of the method of brackets. Part 2
(De Gruyter, 2020) Gonzalez, Ivan; Jiu, Lin; Moll, Victor H.
The method of brackets, developed in the context of evaluation of integrals coming from Feynman diagrams, is a procedure to evaluate definite integrals over the half-line. This method consists of a small number of operational rules devoted to convert the integral into a bracket series. A second small set of rules evaluates this bracket series and produces the result as a regular series. The work presented here combines this method with the classical Mellin transform to extend the class of integrands where the method of brackets can be applied. A selected number of examples are used to illustrate this procedure.
The Gaia-ESO Survey: detection and characterisation of single-line spectroscopic binaries
(European Southern Observatory, 2020) Bayo, Amelia
Context. Multiple stellar systems play a fundamental role in the formation and evolution of stellar populations in galaxies. Recent and ongoing large ground-based multi-object spectroscopic surveys significantly increase the sample of spectroscopic binaries (SBs) allowing analyses of their statistical properties. Aims. We investigate the repeated spectral observations of the Gaia-ESO Survey internal data release 5 (GES iDR5) to identify and characterise SBs with one visible component (SB1s) in fields covering mainly the discs, the bulge, the CoRot fields, and some stellar clusters and associations. Methods. A statistical χ2-test is performed on spectra of the iDR5 subsample of approximately 43 500 stars characterised by at least two observations and a signal-to-noise ratio larger than three. In the GES iDR5, most stars have four observations generally split into two epochs. A careful estimation of the radial velocity (RV) uncertainties is performed. Our sample of RV variables is cleaned from contamination by pulsation- and/or convection-induced variables using Gaia DR2 parallaxes and photometry. Monte-Carlo simulations using the SB9 catalogue of spectroscopic orbits allow to estimate our detection efficiency and to correct the SB1 rate to evaluate the GES SB1 binary fraction and its relation to effective temperature and metallicity. Results. We find 641 (resp., 803) FGK SB1 candidates at the 5σ (resp., 3σ) level. The maximum RV differences range from 2.2 km s−1 at the 5σ confidence level (1.6 km s−1 at 3σ) to 133 km s−1 (in both cases). Among them a quarter of the primaries are giant stars and can be located as far as 10 kpc. The orbital-period distribution is estimated from the RV standard-deviation distribution and reveals that the detected SB1s probe binaries with log P[d] ⪅ 4. We show that SB1s with dwarf primaries tend to have shorter orbital periods than SB1s with giant primaries. This is consistent with binary interactions removing shorter period systems as the primary ascends the red giant branch. For two systems, tentative orbital solutions with periods of 4 and 6 d are provided. After correcting for detection efficiency, selection biases, and the present-day mass function, we estimate the global GES SB1 fraction to be in the range 7–14% with a typical uncertainty of 4%. A small increase of the SB1 frequency is observed from K- towards F-type stars, in agreement with previous studies. The GES SB1 frequency decreases with metallicity at a rate of (−9 ± 3)% dex−1 in the metallicity range −2.7 ≤ [Fe/H] ≤ +0.6. This anticorrelation is obtained with a confidence level higher than 93% on a homogeneous sample covering spectral types FGK and a large range of metallicities. When the present-day mass function is accounted for, this rate turns to (−4 ± 2)% dex−1 with a confidence level higher than 88%. In addition we provide the variation of the SB1 fraction with metallicity separately for F, G, and K spectral types, as well as for dwarf and giant primaries.
Vulnerability of a top marine predator to coastal storms: a relationship between hydrodynamic drivers and stranding rates of newborn pinnipeds
(Springer Nature, 2020) Sepúlveda, M.; Quiñones, R. A.; Esparza, C.; Carrasco, P.; Winckler Grez, Patricio
Coastal storms have increased in recent decades, affecting many species, including the South American sea lion (Otaria byronia). Reports of stranded sea lion pups are becoming common in Chile, presumably due to the increase in the frequency and intensity of coastal storms. To validate this assumption, a 10-year database was built by coupling wave generation and coastal propagation models to correlate pure wave parameters (significant wave height Hs, peak period Tp, normalized wave power Hs2 Tp) and wave parameters including the tidal level (maximum surface elevation η, modified wave power η2 Tp) with records of stranded pups in Cobquecura, the largest breeding colony in central Chile. The correlation between the number of pups stranded per day and wave parameters in the first half of January and the last half of February is poor, while they are stronger for the second half of January and the first half of February. The higher number of stranded pups coincide with coastal storms with normalized wave power values exceeding a threshold of 100 m2/ s. Conversely, below this threshold there is wide dispersion between the number of strandings and wave parameters. Identifying wave parameter thresholds could be used to predict when newborn pups will be most affected by coastal storms, and thus help institutions to develop remediation techniques for animals at risk.
Sulfur or Pollen? Chemical, Biological, and Toxicological Basis for the Correct Risk Communication of Urban Yellow Dust Deposition
(Springer Nature, 2020) Ojeda, Juan; Goddard, Marcela; Cavieres, María Fernanda
Urban yellow dust deposition is a common phenomenon in many parts of the world, which is sometimes called “sulfur shower,” “sulfur rain,” or “pollen storm.” Most people, especially those living in the vicinity of industrial facilities, wrongly perceive the yellow dust as sulfur when in fact it is pollen. The misunderstanding increases risk perception as people believe the “yellow powder” is a serious threat to their health. Based on simple observations, it is virtually impossible to differentiate sulfur from pollen, so risk communication should consider the chemical, biological, and toxicological aspects of these agents. In this review, we clarify that industrial emissions of sulfur are under the form of sulfides, oxides, and other volatile compounds which are gaseous and noncolored, and we explain that it is chemically impossible for gaseous sulfur to become solid yellow sulfur under normal environmental conditions. We also describe pollen and its release from trees, shrubs, and herbs a process influenced by atmospheric conditions. We suggest take-home messages that risk communicators may use when explaining the phenomenon to their communities.
Effect of the Incorporation of Ni in the Adsorption Capacity of Paracetamol (N-Acetyl-P-Aminophenol) on MIL-101(Cr).
(Springer Nature, 2020) Ojeda, Juan
The effect of nickel in the adsorption of Nacetyl-p-aminophenol (paracetamol) on a metal-organic frameworks (MOFs) type MIL-101(Cr) was studied. The incorporation of Ni to MOFs adsorbent was carried out by impregnation and adjusted to give a 4.00 wt.% Ni. The adsorbents were characterized by specific surface area (SSA), surface acidity techniques, electrophoretic migration (EM), thermogravimetric analysis (TGA), and scanning electron microscope (SEM) and were tested by the adsorption of paracetamol solutions. The results showed that the Ni particles were well dispersed throughout the MIL-101(Cr) crystal increasing the acid strength and the density of acid site values in the MOFs surface. The increase in adsorption capacity of MIL-101(Cr) when Ni was incorporated can be attributed to the availability of metal atoms as adsorption centers that can adsorb the paracetamol by electronic retro-donation through π-type complexing.
Evidencia científica sobre cuidados de Enfermería y COVID-19
(Ecimed, 2020) Guerrero-Nancuante, Camilo; Armstrong-Barea, Lucy; González-Adonis1, Francisca
Introducción: COVID-19 ha generado efectos negativos en gran parte del mundo. Su rápida propagación produjo la necesidad de investigar respecto a los cuidados de enfermería otorgados a las comunidades en el contexto de pandemia de SARS CoV2. Objetivo: analizar la evidencia científica disponible respecto a cuidados de enfermería y COVID-19. Métodos: Se realizó una revisión de alcance mediante el marco metodológico de PRISMA-ScR, en bases de datos científicas EMBASE, Scopus, PubMed, Web of Science y otras fuentes de consulta para articulo publicados en inglés entre 1 de diciembre 2019 al 27 de junio 2020. Se analizó fecha de publicación, país de origen y género del primer autor, tipo de artículo y dimensión o tópico de la investigación. Se incluyeron en total 205 artículos. Conclusiones: El 55,61% correspondió a investigaciones realizadas por mujeres como primera autora; el 37,56% de los estudios analizados fueron desarrollados en Estados Unidos. El 68,78% de los manuscritos corresponden a editoriales, comentarios/reflexiones, revisiones e investigaciones primarias. El 63,91% de las publicaciones se relacionaron a tópicos de prácticas de enfermería, rol profesional, salud mental y adultez mayor. Existen baja diversificación temática de los estudios asociados a cuidados de enfermería y COVID-19, como también investigaciones que permitan evaluar las intervenciones disciplinares en el actual contexto. Urge mayor participación femenina en los estudios en dicho ámbito, además de proyectar investigaciones en otras poblaciones vulnerables.
Study of the Nucleation and Growth Mechanisms of Copper Electrodeposition on Bare and Nitrogen-Doped Reduced Graphene Oxide Modified SnO2:F/glass Substrates
(The Electrochemical Society, 2020) Riveros, G.; León, M.; Ramírez, D.; Hernández, L.; Martín, F.; Romero, R.; Dalchiele, Enrique A.
In this article, the influence of a nitrogen-doped electrochemically reduced graphene oxide layer on the nucleation and growth mechanisms of copper electrodeposition was studied. Thus, copper electrodeposition from an acidic solution was evaluated using two different substrates: fluorine-doped tin oxide (FTO), and fluorine-doped tin oxide covered with a nitrogen-doped reduced graphene oxide layer (FTO/N-ERGO). In both cases, chronoamperometric curves were obtained, which were analyzed and deconvoluted using pre-established models and equations, where the different contribution and nucleation parameters were determined. Field emission scanning electron microscopy (FESEM) images were acquired in order to observe the morphology and verify the nuclei density for each case considered in this study. In the case of copper electrodeposition onto FTO, an instantaneous three-dimensional nucleation was observed, together with a proton reduction reaction. When FTO/N-ERGO was used as a substrate, a new instantaneous two-dimensional nucleation process was observed in addition to the processes previously described. Furthermore, the increased density of active sites and the changes in copper morphology are directly related with the N-ERGO layer, which also increased the kinetic constant for the proton reduction reaction and the nucleation rate per active site during the copper electrodeposition process.
The Gaia-ESO survey: 3D NLTE abundances in the open cluster NGC 2420 suggest atomic diffusion and turbulent mixing are at the origin of chemical abundance variations
(European Southern Observatory, 2020)
Context. Atomic diffusion and mixing processes in stellar interiors influence the structure and the surface composition of stars. Some of these processes cannot yet be modelled from the first principles, and they require calibrations. This limits their applicability in stellar models used for studies of stellar populations and Galactic evolution. Aims. Our main goal is to put constraints on the stellar structure and evolution models using new refined measurements of the chemical composition in stars of a Galactic open cluster. Methods. We used medium-resolution, 19 200 ≤ R ≤ 21 500, optical spectra of stars in the open cluster NGC 2420 obtained within the Gaia-ESO survey. The sample covers all evolutionary stages from the main sequence to the red giant branch. Stellar parameters were derived using a combined Bayesian analysis of spectra, 2MASS photometry, and astrometric data from Gaia DR2. The abundances of Mg, Ca, Fe, and Li were determined from non-local thermodynamic equilibrium (NLTE) synthetic spectra, which were computed using one-dimensional (1D) and averaged three-dimensional (3D) model atmospheres. We compare our results with a grid of Code d’Evolution Stellaire Adaptatif et Modulaire (CESTAM) stellar evolution models, which include atomic diffusion, turbulent, and rotational mixing. Results. We find prominent evolutionary trends in the abundances of Fe, Ca, Mg, and Li with the mass of the stars in the cluster. Furthermore, Fe, Mg, and Ca show a depletion at the cluster turn-off, but the abundances gradually increase and flatten near the base of the red giant branch. The abundance trend for Li displays a signature of rotational mixing on the main sequence and abrupt depletion on the sub-giant branch, which is caused by advection of Li-poor material to the surface. The analysis of abundances combined with the CESTAM model predictions allows us to place limits on the parameter space of the models and to constrain the zone in the stellar interior, where turbulent mixing takes place.
Valorization of Globe Artichoke (Cynara scolymus) Agro-Industrial Discards, Obtaining an Extract with a Selective Effect on Viability of Cancer Cell Lines
(MDPI, 2020) Weinstein, Caroline
Globe artichoke (Cynara scolymus L.) is considered one of the most significant sources of phenolic antioxidants in nature. However, more than 60% of its total volume is discarded for consumption purposes, making available an abundant, inexpensive and profitable source of natural antioxidants in the discarded fractions. Polyphenolic antioxidants from a South American variety of artichoke agro-industrial discards (external bracts and stems) were obtained by mild extraction processes. Best results were achieved at 40 °C, 75% of ethanol and 10 min of reaction, obtaining 2.16 g gallic acid equivalent (GAE)/100 g of total phenolic compounds (TPC) and 55,472.34 µmol Trolox equivalent (TE)/100 g of antioxidant capacity (oxygen radical absorbance capacity (ORAC)). High-performance liquid chromatography (HPLC) analyses determined that caffeoylquinic acids comprise up to 85% of the total polyphenolic content, and only around 5% are flavonoids. Inulin content in the artichokes residues was recovered (48.4% dry weight (dw)), resulting in an extract with 28% of inulin in addition to the aforementioned antioxidant capacity. The artichoke discard extract in a concentration of 500 mg/L produced a strong decrease in Caco-2 and MCF-7 cancer cell lines viability, whereas healthy fibroblasts maintained their viability when the extract was concentrated at 1500 mg/L. These results suggest that the artichoke extract presents a good anti-proliferative potential effect on Caco-2 and MCF-7 cells.
Evidence of climate-driven changes on atmospheric, hydrological, and oceanographic variables along the Chilean coastal zone
(Springer, 2020) Winckler Grez, Patricio; Aguirre, Catalina; Farías, Laura; Contreras-López, Manuel; Masotti, Ítalo
The Chilean coastal zone (CCZ) is subjected to a complex spectrum of anthropogenic, geophysical, biogeochemical, and climate-driven perturbations. Potentially affected variables including atmospheric sea level pressure (Pa), alongshore wind, sea surface temperature (SST), chlorophyll-a, rainfall, river discharge, relative mean sea level (RMSL), and wave climate are studied using in situ and satellite records, hindcasts, and reanalysis datasets. Linear temporal trends and correlations of anomalies are estimated between 18°S and 55°S along the CCZ. The comparison of some of the variables is achieved by means of a strict homogenization procedure on a monthly basis for 35 years. Our findings show that the poleward drift and strengthening of the Southeast Pacific Subtropical Anticyclone (SPSA) partially explains the increase in Pa and reduction in rainfall and river discharge. The enhancement of alongshore winds, also attributable to changes in the SPSA, increases coastal upwelling, which in turn could reduce SST and increase chlorophyll-a. Despite differential latitudinal responses, increasing wave heights and a southward rotation are evidenced. RMSL does not show significant variation as it is presumably affected by seafloor changes during the seismic cycle. Though some correlations are evidenced, the influence of climate variability at decadal scale (PDO, SAM) may be affecting the detected trends due to the short length of available data. Impacts on coastal communities, infrastructure, and ecosystems are discussed, aiming to highlight that coastal vulnerabilities and risk management should be based on the cumulative impacts of these variables.

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