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(Ril editores, 2016) Del Barrio Vásquez, Diego
Taxanes for advanced non-small cell lung cancer (Protocol)
(Cochrane, 2018) Madrid, Eva; Barros Monge, Manuel J; Urrútia, Gerard; Roqué I Figuls, Marta; Pérez Bracchiglione, Javier; Vargas Peirano, Manuel; Loézar Hernández, Cristóbal Nicolás; Bonfill Cosp, Xavier
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of taxanes as part of a combined or single‐agent therapy versus other agents or best supportive care as first‐ or second‐line treatment for advanced non‐small cell lung cancer (NSCLC). A secondary objective is to assess different modes or schemes of administration of taxanes in patients with this disease.
Chaos versus noise as drivers of multistability in neural networks
(Chaos, 2018-10-18) Orio, Patricio; Gatica, Marilyn; Herzog, Rubén; Maidana, Jean Paul; Castro, Samy; Xu, Kesheng
The multistable behavior of neural networks is actively being studied as a landmark of ongoing cerebral activity, reported in both functional Magnetic Resonance Imaging (fMRI) and electro- or magnetoencephalography recordings. This consists of a continuous jumping between different partially synchronized states in the absence of external stimuli. It is thought to be an important mechanism for dealing with sensory novelty and to allow for efficient coding of information in an ever-changing surrounding environment. Many advances have been made to understand how network topology, connection delays, and noise can contribute to building this dynamic. Little or no attention, however, has been paid to the difference between local chaotic and stochastic influences on the switching between different network states. Using a conductance-based neural model that can have chaotic dynamics, we showed that a network can show multistable dynamics in a certain range of global connectivity strength and under deterministic conditions. In the present work, we characterize the multistable dynamics when the networks are, in addition to chaotic, subject to ion channel stochasticity in the form of multiplicative (channel) or additive (current) noise. We calculate the Functional Connectivity Dynamics matrix by comparing the Functional Connectivity (FC) matrices that describe the pair-wise phase synchronization in a moving window fashion and performing clustering of FCs. Moderate noise can enhance the multistable behavior that is evoked by chaos, resulting in more heterogeneous synchronization patterns, while more intense noise abolishes multistability. In networks composed of nonchaotic nodes, some noise can induce multistability in an otherwise synchronized, nonchaotic network. Finally, we found the same results regardless of the multiplicative or additive nature of noise.
Characterization of Retinal Functionality at Different Eccentricities in a Diurnal Rodent
(Frontiers in Cellular Neuroscience, 2018-12-03) Escobar, María José; Reyes, César; Herzog, Rubén; Araya, Joaquín; Otero, Mónica; Ibaceta, Cristóbal; Palacios, Adrián G.
Although the properties of the neurons of the visual system that process central and peripheral regions of the visual field have been widely researched in the visual cortex and the LGN, they have scarcely been documented for the retina. The retina is the first step in integrating optical signals, and despite considerable efforts to functionally characterize the different types of retinal ganglion cells (RGCs), a clear account of the particular functionality of cells with central vs. peripheral fields is still wanting. Here, we use electrophysiological recordings, gathered from retinas of the diurnal rodent Octodon degus, to show that RGCs with peripheral receptive fields (RF) are larger, faster, and have shorter transient responses. This translates into higher sensitivity at high temporal frequencies and a full frequency bandwidth when compared to RGCs with more central RF. We also observed that imbalances between ON and OFF cell populations are preserved with eccentricity. Finally, the high diversity of functional types of RGCs highlights the complexity of the computational strategies implemented in the early stages of visual processing, which could inspire the development of bio-inspired artificial systems.
Pre‐ and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption
(Wiley, 2019) Plaza, Wladimir; Gaschino, Felice; Gutiérrez, Camilo; Santibañez, Nicolás; Estay‐Olmos, Camila; Sotomayor‐Zárate, Ramón; De la Fuente‐Ortega, Erwin; Pautass, Ricardo M.; Haeger, Paola A.
Repeated exposure to alcohol increases retrieval of fear‐conditioned memories, which facilitates, among other factors, the emergence of post‐traumatic stress disorder (PTSD). Individuals with PTSD are more likely to develop alcohol and substance abuse related disorders. We assessed if prenatal and early postnatal alcohol exposure (PAE) increased the susceptibility to retain aversive memories and if this was associated with subsequent heightened alcohol consumption. Pregnant Sprague‐Dawley rats were exposed for 22 hr/day, throughout pregnancy and until postnatal Day 7 to a single bottle of sucralose ‐ sweetened 10% alcohol solution (PAE Group), or to a single bottle of tap water and sucralose (Control Group). Auditory fear conditioning (AFC) was performed in the adolescent offspring at postnatal Day 40. Freezing was measured during acquisition, retention and extinction phases, followed by 3 weeks of free choice alcohol intake. Female, but not male, PAE rats exhibited impaired extinction of the aversive memory, a finding associated with higher levels of 3‐4 Dihidroxyphenylacetic acid (DOPAC) in the nucleus accumbens and heightened alcohol intake, respect to controls. These findings suggest that PAE makes females more vulnerable to long‐term retention of aversive memories, which coexist with heightened alcohol intake. These findings are reminiscent of those of PTSD
Development of Fixed Dose Combination Products Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy
(Springer, 2019) Hens, Bart; Corsetti, Maura; Bermejo, Marival; Löbenberg, Raimar; González, Pablo M.; Mitra, V; Desai, Divyakant; Murthy Chilukuri, Dakshina; Aceituno, Alexis
The gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature poses a great challenge for formulation scientists when developing more complex dosage forms such as those combining two or more drugs. Fixed dose combination (FDC) products are two or more single active ingredients combined in a single dosage form. This formulation strategy represents a novel formulation which is as safe and effective compared to every mono-product separately. A complex drug product, to be dosed through a complex route, requires judicious considerations for formulation development. Additionally, it represents a challenge from a regulatory perspective at the time of demonstrating bioequivalence (BE) for generic versions of such drug products. This report gives the reader a summary of a 2-day short course that took place on the third and fourth of November at the Annual Association of Pharmaceutical Scientists (AAPS) meeting in 2018 at Washington, D.C. This manuscript will offer a comprehensive view of the most influential aspects of the GI physiology on the absorption of drugs and current techniques to help understand the fate of orally ingested drug products in the complex environment represented by the GI tract. Through case studies on FDC product development and regulatory issues, this manuscript will provide a great opportunity for readers to explore avenues for successfully developing FDC products and their generic versions.
Inclusión de salud basada en evidencia en carreras de la salud en Chile y el modelo integrado Metodología de la Investigación Científica-Medicina Basada en Evidencia en la Universidad de Valparaíso
(Elsevier, 2019) Papuzinski, Cristian; Loézar, Cristóbal; Carvajal, Natalia; Vargas, Manuel; Borgeat, Marjorie; Madrid, Eva; Pérez-Bracchiglione, Javier; Arancibia, Marcelo
Introducción: La salud basada en evidencia (SBE) integra el uso de la mejor evidencia, la experiencia clínica y los valores y preferencias del paciente para la toma de decisiones. Su incorporación en las carreras sanitarias de Chile es desconocida. Métodos: Se realizó un estudio de corte transversal para evaluar la incorporación de SBE en los programas de las carreras sanitarias en Chile hasta 2019. Se describe la integración del modelo Metodología de la Investigación Científica (MIC)-Medicina Basada en la Evidencia (MBE) en la Escuela de Medicina de la Universidad de Valparaíso. Resultados: Un total de 49 universidades imparten carreras sanitarias. Un 8,13% incorpora SBE como asignatura explícitamente. Todas incorporan asignaturas que potencialmente incluyen contenidos de SBE. Las carreras de Medicina y Enfermería son las que más incorporan SBE, pero solo una carrera de Medicina incluye SBE como asignatura por más de un semestre. El modelo integrado MIC/MBE (4 semestres), orientado en competencias y centrado en el alumno, involucra el diseno ̃ y ejecución de un protocolo de investigación, así como el análisis crítico de la mejor evidencia, integrado con los valores de los pacientes. Conclusión: La incorporación de SBE como asignatura es muy infrecuente en carreras sanitarias chilenas. Se enfatiza su inclusión transdisciplinaria como asignatura individual desde un modelo que integre la ensenanza ̃ de MIC, sobre todo en universidades estatales.
A Comparison of the Maximum Entropy Principle Across Biological Spatial Scales
(Entropy, 2019-10-15) Cofré, Rodrigo; Herzog, Rubén; Corcoran, Derek; Rosas, Fernando E.
Despite their differences, biological systems at different spatial scales tend to exhibit common organizational patterns. Unfortunately, these commonalities are often hard to grasp due to the highly specialized nature of modern science and the parcelled terminology employed by various scientific sub-disciplines. To explore these common organizational features, this paper provides a comparative study of diverse applications of the maximum entropy principle, which has found many uses at different biological spatial scales ranging from amino acids up to societies. By presenting these studies under a common approach and language, this paper aims to establish a unified view over these seemingly highly heterogeneous scenarios.
Tercermundismo y No Alineamiento en América latina durante la Guerra Fría
(Ediciones Inubicalistas, 2020) Alburquerque, Germán
The Gaia-ESO Survey: Spectroscopic-asteroseismic analysis of K2 stars in Gaia-ESO
(European Southern Observatory, 2020) Bayo, Amelia
Context. The extensive stellar spectroscopic datasets that are available for studies in Galactic Archeaology thanks to, for example, the Gaia-ESO Survey, now benefit from having a significant number of targets that overlap with asteroseismology projects such as Kepler, K2, and CoRoT. Combining the measurements from spectroscopy and asteroseismology allows us to attain greater accuracy with regard to the stellar parameters needed to characterise the stellar populations of the Milky Way. Aims. The aim of this Gaia-ESO Survey special project is to produce a catalogue of self-consistent stellar parameters by combining measurements from high-resolution spectroscopy and precision asteroseismology. Methods. We carried out an iterative analysis of 90 K2@Gaia-ESO red giants. The spectroscopic values of Teff were used as input in the seismic analysis to obtain log g values. The seismic estimates of log g were then used to re-determine the spectroscopic values of Teff and [Fe/H]. Only one iteration was required to obtain parameters that are in good agreement for both methods and, thus, to obtain the final stellar parameters. A detailed analysis of outliers was carried out to ensure a robust determination of the parameters. The results were then combined with Gaia DR2 data to compare the seismic log g with a parallax-based log g and to investigate instances of variations in the velocity and possible binaries within the dataset. Results. This analysis produced a high-quality catalogue of stellar parameters for 90 red giant stars from K2@Gaia-ESO that were determined through iterations between spectroscopy and asteroseismology. We compared the seismic gravities with those based on Gaia parallaxes to find an offset which is similar to other studies that have used asteroseismology. Our catalogue also includes spectroscopic chemical abundances and radial velocities, as well as indicators for possible binary detections.
Experimental Framework to Simulate Rescue Operations after a Natural Disaster
(Universidad Nacional de La Plata: Facultad de Informática, 2020) Veas-Castillo, Luis; Ovando-Leon, Gabriel; Astudillo, Gabriel; Gil-Costa, Veronica; Marín, Mauricio
Computational simulation is a powerful tool for performance evaluation of computational systems. It is useful to make capacity planning of data center clusters, to obtain profiling reports of software applications and to detect bottlenecks. It has been used in different research areas like large scale Web search engines, natural disaster evacuations, computational biology, human behavior and tendency, among many others. However, properly tuning the parameters of the simulators, defining the scenarios to be simulated and collecting the data traces is not an easy task. It is an incremental process which requires constantly comparing the estimated metrics and the flow of simulated actions against real data. In this work, we present an experimental framework designed for the development of large scale simulations of two applications used upon the occurrence of a natural disaster strikes. The first one is a social application aimed to register volunteers and manage emergency campaigns and tasks. The second one is a benchmark application a data repository named MongoDB. The applications are deployed in a distributed platform which combines different technologies like a Proxy, a Containers Orchestrator, Containers and a NoSQL Database. We simulate both applications and the architecture platform. We validate our simulators using real traces collected during simulacrums of emergency situations.
Cytotoxic activity of crude extracts and fractions from Blepharocalyx cruckshanksii against selected human cancer cell lines
(Ms Editions, 2020) Baez, Carolina; Villena, Joan; Montenegro, Iván; Russo, Alessandra; Said, Bastian; Madrid, Alejandro
El presente estudio tiene como objetivo explorar las posibles aplicaciones de los extractos de corteza y hoja de Blepharocalyx cruckshanksii como agente citotóxico contra líneas celulares de cáncer in vitro ((MCF-7, PC-3 y HT-29) mediante el uso de ensayo de sulforhodamine B (SRB). El ensayo de citotoxicidad reveló que el extracto de acetato de etilo de la corteza exhibía una actividad anticancerígena marcada. El extracto activo se sometió a un reparto líquido-líquido usando hexano y acetato de etilo para obtener fracciones basadas en su polaridad. Sin embargo, la Fracción 4 (F4) fue identificado como el más efectivo de la serie al mostrar contra todas las líneas celulares de cáncer una citotoxicidad cercana a los agentes antineoplásicos ensayados. Luego, F4 se analizó por cromatografía de gases-espectrometría de masas (GC-MS) para identificar sus componentes principales y relacionar estos componentes con el efecto citotóxico. Los resultados obtenidos indicaron que la corteza de B. cruckshanksii tiene una excelente actividad citotóxica y amerita estudios adicionales para aislar nuevos compuestos para quimioterapia.
A mechanistic model of the neural entropy increase elicited by psychedelic drugs
(Nature.com, 2020) Herzog, Rubén; Cofré, Rodrigo
Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity
Assessment of Native and Endemic Chilean Plants for Removal of Cu, Mo and Pb from Mine Tailings
(MDPI, 2020) Lazo, Pamela; Lazo, Andrea
In Chile, 85% of tailings impoundments are inactive or abandoned and many of them do not have a program of treatment or afforestation. The phytoremediation of tailings with Oxalis gigantea, Cistanthe grandiflora, Puya berteroniana and Solidago chilensis have been tested in order to find plants with ornamental value and low water requirements, which enable reductions in molybdenum (Mo), copper (Cu) or lead (Pb) concentrations creating an environmentally friendly surrounding. Ex-situ phytoremediation experiments were carried out for seven months and Mo, Cu and Pb were measured at the beginning and at the end of the growth period. The capacity of these species to phyto-remedy was evaluated using the bioconcentration and translocation factors, along with assessing removal efficiency. Solidago chilensis showed the ability to phytoextract Mo while Puya berteroniana showed potential for Cu and Mo stabilization. The highest removal efficiencies were obtained for Mo, followed by Cu and Pb. The maximum values of removal efficiency for Mo, Cu and Pb were 28.7% with Solidago chilensis, 15.6% with Puya berteroniana and 8.8% with Cistanthe grandiflora, respectively. Therefore, the most noticeable results were obtained with Solidago chilensis for phytoextraction of Mo.
Evidencia científica sobre cuidados de Enfermería y COVID-19
(Ecimed, 2020) Guerrero-Nancuante, Camilo; Armstrong-Barea, Lucy; González-Adonis1, Francisca
Introducción: COVID-19 ha generado efectos negativos en gran parte del mundo. Su rápida propagación produjo la necesidad de investigar respecto a los cuidados de enfermería otorgados a las comunidades en el contexto de pandemia de SARS CoV2. Objetivo: analizar la evidencia científica disponible respecto a cuidados de enfermería y COVID-19. Métodos: Se realizó una revisión de alcance mediante el marco metodológico de PRISMA-ScR, en bases de datos científicas EMBASE, Scopus, PubMed, Web of Science y otras fuentes de consulta para articulo publicados en inglés entre 1 de diciembre 2019 al 27 de junio 2020. Se analizó fecha de publicación, país de origen y género del primer autor, tipo de artículo y dimensión o tópico de la investigación. Se incluyeron en total 205 artículos. Conclusiones: El 55,61% correspondió a investigaciones realizadas por mujeres como primera autora; el 37,56% de los estudios analizados fueron desarrollados en Estados Unidos. El 68,78% de los manuscritos corresponden a editoriales, comentarios/reflexiones, revisiones e investigaciones primarias. El 63,91% de las publicaciones se relacionaron a tópicos de prácticas de enfermería, rol profesional, salud mental y adultez mayor. Existen baja diversificación temática de los estudios asociados a cuidados de enfermería y COVID-19, como también investigaciones que permitan evaluar las intervenciones disciplinares en el actual contexto. Urge mayor participación femenina en los estudios en dicho ámbito, además de proyectar investigaciones en otras poblaciones vulnerables.
Effect of the Incorporation of Ni in the Adsorption Capacity of Paracetamol (N-Acetyl-P-Aminophenol) on MIL-101(Cr).
(Springer Nature, 2020) Ojeda, Juan
The effect of nickel in the adsorption of Nacetyl-p-aminophenol (paracetamol) on a metal-organic frameworks (MOFs) type MIL-101(Cr) was studied. The incorporation of Ni to MOFs adsorbent was carried out by impregnation and adjusted to give a 4.00 wt.% Ni. The adsorbents were characterized by specific surface area (SSA), surface acidity techniques, electrophoretic migration (EM), thermogravimetric analysis (TGA), and scanning electron microscope (SEM) and were tested by the adsorption of paracetamol solutions. The results showed that the Ni particles were well dispersed throughout the MIL-101(Cr) crystal increasing the acid strength and the density of acid site values in the MOFs surface. The increase in adsorption capacity of MIL-101(Cr) when Ni was incorporated can be attributed to the availability of metal atoms as adsorption centers that can adsorb the paracetamol by electronic retro-donation through π-type complexing.
Sulfur or Pollen? Chemical, Biological, and Toxicological Basis for the Correct Risk Communication of Urban Yellow Dust Deposition
(Springer Nature, 2020) Ojeda, Juan; Goddard, Marcela; Cavieres, María Fernanda
Urban yellow dust deposition is a common phenomenon in many parts of the world, which is sometimes called “sulfur shower,” “sulfur rain,” or “pollen storm.” Most people, especially those living in the vicinity of industrial facilities, wrongly perceive the yellow dust as sulfur when in fact it is pollen. The misunderstanding increases risk perception as people believe the “yellow powder” is a serious threat to their health. Based on simple observations, it is virtually impossible to differentiate sulfur from pollen, so risk communication should consider the chemical, biological, and toxicological aspects of these agents. In this review, we clarify that industrial emissions of sulfur are under the form of sulfides, oxides, and other volatile compounds which are gaseous and noncolored, and we explain that it is chemically impossible for gaseous sulfur to become solid yellow sulfur under normal environmental conditions. We also describe pollen and its release from trees, shrubs, and herbs a process influenced by atmospheric conditions. We suggest take-home messages that risk communicators may use when explaining the phenomenon to their communities.
The Gaia-ESO Survey: detection and characterisation of single-line spectroscopic binaries
(European Southern Observatory, 2020) Bayo, Amelia
Context. Multiple stellar systems play a fundamental role in the formation and evolution of stellar populations in galaxies. Recent and ongoing large ground-based multi-object spectroscopic surveys significantly increase the sample of spectroscopic binaries (SBs) allowing analyses of their statistical properties. Aims. We investigate the repeated spectral observations of the Gaia-ESO Survey internal data release 5 (GES iDR5) to identify and characterise SBs with one visible component (SB1s) in fields covering mainly the discs, the bulge, the CoRot fields, and some stellar clusters and associations. Methods. A statistical χ2-test is performed on spectra of the iDR5 subsample of approximately 43 500 stars characterised by at least two observations and a signal-to-noise ratio larger than three. In the GES iDR5, most stars have four observations generally split into two epochs. A careful estimation of the radial velocity (RV) uncertainties is performed. Our sample of RV variables is cleaned from contamination by pulsation- and/or convection-induced variables using Gaia DR2 parallaxes and photometry. Monte-Carlo simulations using the SB9 catalogue of spectroscopic orbits allow to estimate our detection efficiency and to correct the SB1 rate to evaluate the GES SB1 binary fraction and its relation to effective temperature and metallicity. Results. We find 641 (resp., 803) FGK SB1 candidates at the 5σ (resp., 3σ) level. The maximum RV differences range from 2.2 km s−1 at the 5σ confidence level (1.6 km s−1 at 3σ) to 133 km s−1 (in both cases). Among them a quarter of the primaries are giant stars and can be located as far as 10 kpc. The orbital-period distribution is estimated from the RV standard-deviation distribution and reveals that the detected SB1s probe binaries with log P[d] ⪅ 4. We show that SB1s with dwarf primaries tend to have shorter orbital periods than SB1s with giant primaries. This is consistent with binary interactions removing shorter period systems as the primary ascends the red giant branch. For two systems, tentative orbital solutions with periods of 4 and 6 d are provided. After correcting for detection efficiency, selection biases, and the present-day mass function, we estimate the global GES SB1 fraction to be in the range 7–14% with a typical uncertainty of 4%. A small increase of the SB1 frequency is observed from K- towards F-type stars, in agreement with previous studies. The GES SB1 frequency decreases with metallicity at a rate of (−9 ± 3)% dex−1 in the metallicity range −2.7 ≤ [Fe/H] ≤ +0.6. This anticorrelation is obtained with a confidence level higher than 93% on a homogeneous sample covering spectral types FGK and a large range of metallicities. When the present-day mass function is accounted for, this rate turns to (−4 ± 2)% dex−1 with a confidence level higher than 88%. In addition we provide the variation of the SB1 fraction with metallicity separately for F, G, and K spectral types, as well as for dwarf and giant primaries.
Thermodynamic Formalism in Neuronal Dynamics and Spike Train Statistics
(MDPI, 2020) Cofré, Rodrigo
The Thermodynamic Formalism provides a rigorous mathematical framework for studying quantitative and qualitative aspects of dynamical systems. At its core, there is a variational principle that corresponds, in its simplest form, to the Maximum Entropy principle. It is used as a statistical inference procedure to represent, by specific probability measures (Gibbs measures), the collective behaviour of complex systems. This framework has found applications in different domains of science. In particular, it has been fruitful and influential in neurosciences. In this article, we review how the Thermodynamic Formalism can be exploited in the field of theoretical neuroscience, as a conceptual and operational tool, in order to link the dynamics of interacting neurons and the statistics of action potentials from either experimental data or mathematical models. We comment on perspectives and open problems in theoretical neuroscience that could be addressed within this formalism
International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth
(Wiley, 2020) Flores, Marie Therese
Avulsion of permanent teeth is one of the most serious dental injuries. Prompt and correct emergency management is essential for attaining the best outcome after this injury. The International Association of Dental Traumatology (IADT) has developed these Guidelines as a consensus statement after a comprehensive review of the dental literature and working group discussions. It represents the current best evidence and practice based on that literature search and expert opinions. Experienced researchers and clinicians from various specialties and the general dentistry community were included in the working group. In cases where the published data did not appear conclusive, recommendations were based on consensus opinions or majority decisions of the working group. They were then reviewed and approved by the members of the IADT Board of Directors. The purpose of these Guidelines is to provide clinicians with the most widely accepted and scientifically plausible approaches for the immediate or urgent care of avulsed permanent teeth. The IADT does not, and cannot, guarantee favorable outcomes from adherence to the Guidelines. However, the IADT believes that their application can maximize the probability of favorable outcomes.

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